PMID: 9445021Jan 28, 1998Paper

Distribution of mouse adenovirus type 1 in intraperitoneally and intranasally infected adult outbred mice

Journal of Virology
A E KajonK R Spindler

Abstract

In situ nucleic acid hybridization and immunohistochemistry were used to determine the histological localization of mouse adenovirus type 1 (MAV-1) during acute infection of adult mice infected either intraperitoneally or intranasally with 1,000 PFU of wild-type virus. Organ samples were collected from days 1 to 17 postinfection for the intraperitoneally infected mice and from days 1 to 13 for the intranasally infected mice. Endothelial cells of the brain and spinal cord showed extensive evidence of MAV-1 infection. Endothelial cells in lungs, kidneys, and other organs were also positive for MAV-1, indicating a widespread involvement of the systemic circulation. The presence of viral nucleic acid and/or antigen was also demonstrated in lymphoid tissue. The spleens, Peyer's patches, and peripheral lymph nodes showed positive staining at various times postinfection in mice infected by either route. Virus-infected cells in the spleen exhibited a stellate shape and were localized to the red pulp and germinal centers, suggesting that they are cells of the mononuclear phagocytic system.

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Citations

Nov 16, 2004·Journal of Virology·Lei FangKatherine R Spindler
Jan 30, 2009·Journal of Virology·Sharmila RamanKatherine R Spindler
Jul 3, 2009·Journal of Virology·Lisa E GralinskiKatherine R Spindler
Oct 17, 2012·Heart Failure Reviews·Sabine Pankuweit, Karin Klingel
Oct 17, 2014·Journal of Virology·Mary K McCarthyJason B Weinberg
Mar 20, 2009·Journal of Virology·Boris KlempaAlexander Stang
Feb 7, 2014·Human Gene Therapy·Estrella Lopez-GordoRamon Alemany
Jan 6, 2017·Journal of Virology·Shanna L AshleyKatherine R Spindler
Dec 3, 2016·Journal of Virology·Luiza A Castro-JorgeKatherine R Spindler
Nov 30, 2019·FEBS Letters·Silvio Hemmi, Katherine R Spindler
Nov 17, 2001·Journal of Virology·K R SpindlerA Kajon
Aug 17, 2005·Journal of Virology·Amanda R WeltonKatherine R Spindler
Jun 16, 2016·MSphere·Nagaraja TirumuruKatherine R Spindler
Feb 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katherine R SpindlerElissa J Chesler
Nov 18, 2020·The Pediatric Infectious Disease Journal·Xiao-Fang ZhangSi-Qi Hong

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