PMID: 9523552Apr 2, 1998Paper

Distribution of mRNAs encoding the peroxisome proliferator-activated receptor alpha, beta, and gamma and the retinoid X receptor alpha, beta, and gamma in rat central nervous system

Journal of Neurochemistry
T E CullingfordJ B Clark

Abstract

We report the isolation, by RT-PCR, of partial cDNAs encoding the rat peroxisome proliferator-activated receptor (PPAR) isoforms PPAR alpha, PPAR beta, and PPAR gamma and the rat retinoid X receptor (RXR) isoforms RXR alpha, RXR beta, and RXR gamma. These cDNAs were used to generate antisense RNA probes to permit analysis, by the highly sensitive and discriminatory RNase protection assay, of the corresponding mRNAs in rat brain regions during development. PPAR alpha, PPAR beta, RXR alpha, and RXR beta mRNAs are ubiquitously present in different brain regions during development, PPAR gamma mRNA is essentially undetectable, and RXR gamma mRNA is principally localised to cortex. We demonstrate, for the first time, the presence of PPAR and RXR mRNAs in primary cultures of neonatal meningeal fibroblasts, cerebellar granule neurons (CGNs), and cortical and cerebellar astrocytes and in primary cultures of adult cortical astrocytes. PPAR alpha, PPAR beta, RXR alpha, and RXR beta mRNAs are present in all cell types, albeit that PPAR alpha and RXR alpha mRNAs are at levels near the limit of detection in CGNs. PPAR gamma mRNA is expressed at low levels in most cell types but is present at levels similar to those of PPAR alpha mRNA in adul...Continue Reading

Citations

Sep 24, 2002·The Journal of Biological Chemistry·Kalipada PahanSusan M Fischer
Jul 22, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marta P PereiraMaría A Moro
May 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·Stephanie SchwarzJosef Krieglstein
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Massimo CollinoChristoph Thiemermann
Feb 28, 2009·The European Journal of Neuroscience·Nicoletta SchintuAnna R Carta
Feb 26, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Suresh L Mehta, P Andy Li
Jun 18, 2014·Journal of Neurotrauma·Amy L Bowes, Ping K Yip
Mar 2, 2016·Nutritional Neuroscience·Adriana Morales-MartínezFrancisca Pérez-Severiano
Feb 13, 2016·Metabolic Brain Disease·Abby L DotsonHalina Offner
Jun 11, 2016·Scientific Reports·Anna WardenR Adron Harris
Oct 26, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yen-Che HsiehYi-Chuan Cheng
May 21, 2019·Frontiers in Cellular Neuroscience·Lisandro Jorge Falomir-LockhartAndrés Martín Toscani
Oct 26, 1999·Endocrine Reviews·B Desvergne, W Wahli
May 3, 2003·Diabetes Technology & Therapeutics·Douglas L Feinstein
Jun 24, 2004·Journal of Neuroscience Research·Steven A SmithSarah J Roberts-Thomson
Aug 12, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Denis ArsenijevicPanteleimon Giannakopoulos
Jun 20, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Li LiGary E Isom
Nov 1, 2006·Biochemical Society Transactions·R BordetM Bastide
Jul 23, 2008·PPAR Research·Markus P Kummer, Michael T Heneka
Jun 23, 2010·Nature Reviews. Endocrinology·Anne HiukkaMarja-Riitta Taskinen
Dec 17, 2016·International Journal of Molecular Sciences·Maja GrabackaKrzysztof Reiss
Oct 31, 2015·International Journal of Environmental Research and Public Health·Catherine A SmithJeffrey C Smith
Nov 20, 2015·Metabolic Brain Disease·Abby L DotsonHalina Offner
Jul 22, 2018·Current Medicinal Chemistry·Xin ChenKristopher G Virga
Jul 16, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Annchen R KnodtAhmad R Hariri
Jun 18, 2002·Journal of Neurochemistry·Thomas ZanderMichael T Heneka
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Klára KitajkaLászló G Puskás
Nov 5, 2002·Nature Reviews. Neuroscience·Malcolm Maden
Apr 25, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·P GervoisB Staels

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.