PMID: 6968315Jul 1, 1980Paper

Distribution of muscarinic acetylcholine receptors and presynaptic nerve terminals in amphibian heart

The Journal of Cell Biology
H C Hartzell

Abstract

At many synapses, neurotransmitter receptor molecules in the postsynaptic membrane are selectively concentrated at a site directly opposite the presynaptic nerve terminal. In this paper, I examine acetylcholine (ACh) receptor distribution in cardiac muscle in relatin to the distribution of presynaptic axonal varicosities. The density of varicosities, stained with zinc iodide and osmium, ranges from 0.7/100 micrometer 2 in ventricle to 1.9/100 micrometer 2 in sinus venosus. It is estimated that < 3% of the muscle surface is apposed to presynaptic varicosities. ACh receptors, however, are randomly distributed on the muscle surface and not concentrated in patche. ACh receptor distribution was determined by iontophoretic application of ACh and mapping of ACh sensitivity and by [3H]QNB (quinuclidinyl benzilate) binding and autoradiography [3H]QNB binds with > 90% specificity to a single, saturable, high-affinity (Kd = 11.1 pM at 21 degrees C) class of binding sites. QNB binding sites are thought to correspond to ACh receptors, because muscarinic agonists compete for [3H]QNB binding and produce a hyperpolarization in the sinus venosus with the same order of potency. The concentrations of QNB binding sites in the sinus and atria are a...Continue Reading

References

Jun 1, 1977·Developmental Biology·M A LaneM M Salpeter
Nov 30, 1978·Pflügers Archiv : European journal of physiology·A Noma, W Trautwein
Sep 1, 1979·Pflügers Archiv : European journal of physiology·A NomaW Trautwein
Feb 24, 1976·Pflügers Archiv : European journal of physiology·R Ten EickW Trautwein
Oct 13, 1970·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R I Woods
Oct 13, 1970·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R I Woods
Apr 27, 1971·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·U J McMahan, S W Kuffler
Apr 27, 1971·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A J HarrisM J Dennis
Jun 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·W J GeorgeN D Goldberg
Jun 1, 1970·The American Journal of Anatomy·J C Thaemert
Apr 1, 1966·The Journal of Cell Biology·J C Thaemert
Feb 1, 1967·Journal of Ultrastructure Research·R Hadek, P J Talso
Oct 8, 1963·Zeitschrift für Zellforschung und mikroskopische Anatomie·W TRAUTWEIN, K UCHIZONO

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Citations

Jan 1, 1993·Pflügers Archiv : European journal of physiology·H HeidbüchelE Carmeliet
Mar 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·R LindmarW Weide
Jan 1, 1986·Pflügers Archiv : European journal of physiology·J NedomaS Tucek
Aug 1, 1987·Pflügers Archiv : European journal of physiology·M A Simmons, H C Hartzell
Mar 1, 1981·Pflügers Archiv : European journal of physiology·W OsterriederW Trautwein
Aug 1, 1991·Journal of Bioenergetics and Biomembranes·A M BrownL Birnbaumer
Jan 1, 1988·Progress in Biophysics and Molecular Biology·H C Hartzell
Jun 15, 1992·Journal of the Autonomic Nervous System·M KlemmG Campbell
Jul 1, 1993·Journal of the Autonomic Nervous System·J K ChoateG D Hirst
Jan 1, 1989·Neurochemistry International·A SzabóK Gulya
Jan 1, 1983·Progress in Neurobiology·J J McArdle
Sep 1, 1995·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·S B Jones, L B King
Sep 18, 1990·European Journal of Pharmacology·A P BraunP V Sulakhe
Dec 10, 1999·Journal of the Autonomic Nervous System·M A HansenJ A Barden
Jul 2, 2003·Regulatory Peptides·Maria Carmela CerraBruno Tota
Dec 1, 1996·Progress in Neurobiology·M R Bennett
Dec 1, 1981·The Journal of Cell Biology·S R Hootman, S A Ernst
Jun 1, 1992·Journal of Neurochemistry·F LasbennesJ Seylaz
Oct 25, 1991·Brain Research·B G DingerS J Fidone
Sep 1, 1985·Journal of Neurochemistry·T L Creazzo, H C Hartzell
Jul 21, 1991·Journal of Theoretical Biology·J M ShumakerW R Giles
Mar 1, 1983·Journal of Neurochemistry·P GrammasJ Wiener
Sep 1, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S DheinO E Brodde
Oct 1, 1983·Journal of Molecular and Cellular Cardiology·M L Kirby, R S Aronstam
Jun 18, 1981·Nature·H C Hartzell
Jul 1, 1989·Circulation Research·C Nyquist-Battie, K Trans-Saltzmann
Jul 29, 1993·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·F R EdwardsG D Hirst

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