Distribution of myocardial macrophages in the normal human heart

Journal of Anatomy
M AzzawiI V Hutchinson

Abstract

Macrophages are important in inflammatory processes in heart disease and in transplantation rejection. A resurgence of interest in the macrophage has emanated from recent evidence implicating it as an effector cell in atherosclerosis and transplantation rejection. The detailed distribution of the macrophage within the normal human heart is unknown. We quantified macrophage numbers in the different chambers of the heart. Large tissue blocks (1.5-2.0 cm3) were removed from specific sites in 5 'normal' control hearts (2 males, 3 females, age range 19-46 y). Paraffin-embedded sections were stained with a CD68 pan macrophage marker. Positive cells were enumerated within 20 random fields. Results were analysed using a generalised linear modelling method using the Poisson distribution. Macrophages were identified within septa, and often close to blood vessels, in the myocardium, and in the majority of areas in all hearts. Macrophage numbers varied significantly between areas (range 0-6 cells/high power field; P < 0.001), and between the 5 hearts analysed (P < 0.001). In general, there were significantly more macrophages in the ventricles (RV P < 0.01, LV P < 0.05), but these differences were affected by heart differences. This study p...Continue Reading

References

Jul 26, 1990·The New England Journal of Medicine·B LevineM Packer
May 1, 1989·Journal of Internal Medicine·C P Maury, A M Teppo
Dec 1, 1994·British Heart Journal·A MatsumoriS Sasayama
Mar 1, 1996·Transplant Immunology·D Z AlexanderC P Larsen
Sep 1, 1996·Immunology Today·H W Ziegler-Heitbrock
Jun 1, 1996·Immunology Today·J H PetersF Steinbach

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Citations

Feb 22, 2001·Forensic Science International : Synergy·K IwadateY Ito
Apr 17, 2002·Forensic Science International : Synergy·Reinhard DettmeyerBurkhard Madea
Jul 10, 2003·Forensic Science International : Synergy·Kimiharu IwadateYohko Ito
Jun 21, 2013·PloS One·Keiichi ItoMichihiro Yoshimura
Jul 27, 1999·The Journal of Investigative Dermatology·W KölgenF R de Gruijl
May 11, 2013·Journal of Pharmacological and Toxicological Methods·Kimberly A HendersonBrian M Roche
Apr 28, 2016·Seminars in Cell & Developmental Biology·Jonathan LeorTal Konfino
May 29, 2007·Shock·William R LawJames D Ross
Jul 10, 2019·Journal of Leukocyte Biology·Daniel I PetkovMarcelo J Kuroda
Aug 1, 2020·The American Journal of Forensic Medicine and Pathology·Silvia Farkašová IannacconeDaniel Farkaš

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