Distribution of N-cadherin and NCAM in neurons and endocrine cells of the human embryonic and fetal gastroenteropancreatic system

Acta histochemica
Y A GaidarM Witt

Abstract

For the first time, the distribution of N-cadherin and neural cell adhesion molecule (NCAM) as well as some neuropeptides in nerve cells and endocrine cells of the human embryonic and fetal gastroenteropancreatic system has been detected in early stages (from the 6th postovulatory week onwards). Epithelial cells of the stomach and small intestine contained gastrin and somatostatin and the epithelium of the small intestine also bombesin-positive cells. Myenteric ganglionic cells showed both bombesin and VIP and were NCAM- and N-cadherin-positive at all ages studied. Some basally granulated epithelial cells of stomach, duodenum and the upper part of jejunum contained N-cadherin. The number of these cells increased from 6th to 10th postovulatory weeks. Nerve cells and the cytoplasm of individual epithelial cells of pancreatic ducts were immunoreactive for NCAM and N-cadherin. NCAM- and N-cadherin-positive cells also appeared in Langerhans islets (> 10 weeks), mainly in their peripheral part. NCAM- and N-cadherin-positive endocrine cells were less numerous than endocrine cells producing somatostatin, bombesin, and VIP, probably reflecting the features of embryonic/fetal histogenesis of Langerhans islets from epithelial endocrine ce...Continue Reading

References

Dec 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·O B TerkelsenK Møllgård
Oct 1, 1992·Developmental Biology·R R De KrijgerG J Bruining
Aug 1, 1992·Gastroenterologia Japonica·S IchiyanagiA Yachi
Jul 1, 1990·Differentiation; Research in Biological Diversity·R ProbstmeierM Schachner
Jan 1, 1991·Annual Review of Biochemistry·G M Edelman, K L Crossin
Jan 15, 1990·Experientia·H Anderson
May 1, 1986·Cell Differentiation·D MasquelierC Remacle
Jan 1, 1989·Molecular Neurobiology·I Gozes, D E Brenneman
Jun 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O K LangleyM Gratzl
Sep 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B A SteinJ M Polak
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Aug 15, 1984·American Journal of Obstetrics and Gynecology·R A Munsick
Feb 1, 1983·Regulatory Peptides·J A ChayvialleP M Dubois
Aug 1, 1983·Journal of Neurochemistry·S IbsenE Bock
Feb 1, 1995·Journal of Clinical Pathology·A DoğanJ Spencer
Aug 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D LinnemannE Bock
Jan 1, 1993·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M H Hitselberger KanitzP M Iannaccone
Feb 1, 1993·Anatomy and Embryology·H OtaniO Tanaka
May 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·H M RomanskaJ M Polak

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Citations

Nov 5, 2002·The American Journal of Pathology·Erika RosivatzKarl-Friedrich Becker
Jun 24, 2011·Pancreas·Dorit FabriciusMary Sue O'Dorisio
May 24, 2008·Journal of Medical Case Reports·Angel I PopkharitovDimitar P Sivrev
Jul 5, 2006·Archives of Histology and Cytology·Benio TsuchiyaKiyoshi Mukai
Feb 24, 2007·The Kurume Medical Journal·Yoshiki NaitoMasamichi Kojiro
Nov 28, 2013·Scientifica·Paolo Meda
Feb 22, 2012·Developmental Biology·Florence Broders-BondonSylvie Dufour
Sep 21, 2001·Pathology International·K YanagimotoT Kameya
Jan 13, 2015·Human Psychopharmacology·Laura Orsolini, Cesario Bellantuono
Mar 24, 2021·Scientific Reports·Martha Campbell-ThompsonMark A Atkinson

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