PMID: 9183692Jun 2, 1997Paper

Distribution of neuronal apoptosis inhibitory protein-like immunoreactivity in the rat central nervous system

The Journal of Comparative Neurology
D G XuG S Robertson

Abstract

We have recently shown that spinal muscular atrophy (SMA), an autosomal recessive disorder characterized by motor neuron loss, is associated with deletion of a gene that encodes the neuronal apoptosis inhibitory protein (NAIP). In the present study, we have examined the distribution of NAIP-like immunoreactivity (NAIP-LI) in the rat central nervous system (CNS) by using an affinity-purified polyclonal antibody against NAIP. In the forebrain, immunoreactive neurons were detected in the cortex, the hippocampus (pyramidal cells, dentate granule cells, and interneurons), the striatum (cholinergic interneurons), the basal forebrain (ventral pallidum, medial septal nucleus, and diagonal band), the thalamus (lateral and ventral nuclei), the habenula, the globus pallidus, and the entopenduncular nucleus. In the midbrain, NAIP-LI was located primarily within neurons of the red nucleus, the substantia nigra pars compacta, the oculomotor nucleus, and the trochlear nucleus. In the brainstem, neurons containing NAIP-LI were observed in cranial nerve nuclei (trigeminal, facial, vestibular, cochlear, vagus, and hypoglossal nerves) and in relay nuclei (pontine, olivary, lateral reticular, cuneate, gracile nucleus, and locus coeruleus). In the ...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D W Appleby, S P Modak
Jan 1, 1991·Acta Neuropathologica·S MurayamaK Suzuki
May 6, 1987·Neuroscience Letters·G M PetersonF H Gage
Jan 1, 1985·Acta Neuropathologica·J TowfighiR M Ward
Sep 1, 1980·Annals of Neurology·G S SteimanM J Brown
Jan 1, 1994·The Journal of Cell Biology·J C Reed
Jan 1, 1993·Annual Review of Neuroscience·E M Johnson, T L Deckwerth
Aug 1, 1961·Archives of Neurology·R K BYERS, B Q BANKER

❮ Previous
Next ❯

Citations

Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M HolcikR G Korneluk
May 19, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Johannes K X MaierAlex E MacKenzie
Nov 26, 2003·European Journal of Clinical Investigation·J D OstrowC Tiribelli
Apr 4, 2002·Neuroreport·Jennifer Ingram-CrooksAlex E MacKenzie
Aug 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P MacManus, M D Linnik
Aug 6, 2003·The Journal of Comparative Neurology·Stephanie A Nottingham, Joe E Springer
May 5, 1999·Current Opinion in Neurology·N H Gendron, A E MacKenzie
Apr 14, 2000·Brain Pathology·G S RobertsonJ B Schulz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.