Distribution of neuropeptide W in the rat brain

Neuropeptides
Fumiko TakenoyaSeiji Shioda

Abstract

Neuropeptide W (NPW), which was recently isolated from the porcine hypothalamus, has been identified as the endogenous ligand of the orphan G protein-coupled receptors GPR7 (NPBWR1) and GPR8 (NPBWR2). Infusion of NPW increases food intake in the light phase, whereas in the dark phase, it has the opposite effect. In this study, we used RT-PCR analysis to examine the gene expression of NPW mRNA in the rat brain, and performed a detailed analysis of the distribution of NPW-positive neurons by use of immunohistochemistry at both the light and electron microscopic levels. NPW mRNA expression was demonstrated in the hypothalamic paraventricular nucleus (PVN), arcuate nucleus (ARC), ventromedial nucleus (VMH) and lateral hypothalamus (LH). At the light microscopic level, NPW-like immunoreactive (NPW-LI) cell bodies were found in the preoptic area (POA), PVN, ARC, VMH, LH, PMD (dorsal premammillary nucleus), periaqueductal gray (PAG), lateral parabrachial nucleus (LPB), and prepositus nucleus (Pr). NPW-LI axon terminals were shown in the POA, bed nucleus of the stria terminalis (BST), amygdala, PVN, ARC, VMH, LH, and PAG, LPB. In addition, at the electron microscopic level, NPW-LI cell bodies and dendritic processes were often seen to ...Continue Reading

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Citations

Mar 1, 2012·Neuropharmacology·Jennifer A Parker, Stephen R Bloom
Aug 13, 2015·Research in Veterinary Science·Rui FangZhihai Lei
Mar 21, 2013·Journal of Animal Physiology and Animal Nutrition·T NasoA El-Kirdasy
Jul 17, 2010·Annals of the New York Academy of Sciences·Fumiko TakenoyaSeiji Shioda
Feb 19, 2015·Journal of Molecular Neuroscience : MN·Fumiko TakenoyaSeiji Shioda
Apr 5, 2017·Acta Physiologica·H LiA J Page
Aug 9, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alicia T PateWillis K Samson
Aug 9, 2018·Frontiers in Physiology·Magdalena Chottova Dvorakova
Oct 28, 2020·International Journal of Molecular Sciences·Shashank PandeyMagdalena Chottova Dvorakova

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