PMID: 8962746Dec 1, 1995Paper

Distribution of nickel in body fluids and organs of rats chronically exposed to nickel sulphate

Human & Experimental Toxicology
J SeveraM Cizkova

Abstract

1. Male and female rats were given 100 mg Ni L-1 (as nickel sulphate) in drinking water for 6 months. 2. The feeding of nickel was associated with an increased concentration of nickel in body fluids and organs. The highest concentrations of nickel were found in the liver of both male and female rats. In male rats nickel levels decreased in the order: liver > kidney = whole blood = serum > testes > urine. In female rats the decreasing order was similar: liver > kidney = whole blood = serum = plasma > urine > ovaries. 3. No significant differences were found between nickel concentrations in organs (except ovaries), blood and urine of rats exposed for 3 months and those exposed for 6 months indicating the reaching of a steady state of nickel in the rat during long-term exposure. 4. The urinary excretion of the orally administered nickel was only 2% of absorbed dose (supposing 1% Ni absorption).

References

Jul 1, 1973·Toxicology and Applied Pharmacology·P D Whanger
Oct 1, 1994·Human & Experimental Toxicology·A VyskocilM Cízková
Jan 1, 1994·Medical and Pediatric Oncology·C TeinturierJ Lemerle

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Citations

Sep 23, 2008·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Adriana KolesarovaMonika Schneidgenova
Jun 21, 2013·Biological Trace Element Research·Jiřina KročkováAnton Kováčik
Jan 22, 2011·Molecular Reproduction and Development·Yingbiao SunFrans A van der Hoorn
Oct 18, 2016·Arhiv za higijenu rada i toksikologiju·Imed-Eddine Kadi, Faouzi Dahdouh
Jun 9, 2005·Toxicology and Industrial Health·Chisato KoizumiKoichi Kono

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