Distribution of Notch family proteins in intrauterine growth restriction and hypertension complicated human term placentas

Acta histochemica
Zeliha SahinRamazan Demir

Abstract

Members of the Notch family have been detected in many developmental and cell specification processes during placental development. However, Notch protein expression in Intrauterine Growth Restriction (IUGR) and Pregnancy Induced Hypertension (PIH) is not clear. In this study we aimed to clarify the immunolocalization of Notch proteins in full-term placentas after IUGR and PIH in comparison with normal placentas. Formalin-fixed, paraffin-embedded term placentas obtained by caesarean operations were processed for immunohistochemical localization of Notch 1, 2, 4 and Jagged 2. Transmission electron microscopy was also performed. In normal term placentas, all Notch proteins were intensely immunostained in the brush border of cells of the syncytiotrophoblast layer of the basal (maternal) side and the chorionic plate (fetal) side. The endothelial cells were also intensely immunostained in both sides for Notch 1. However, in IUGR and PIH placentas, the immunoreactivities of all Notch proteins were decreased significantly in the brush border of cells of the syncytiotrophoblast layer and the reaction was generally observed in the cytoplasm of syncytiotrophoblast cells in the basal and chorionic plate sides. The reactivity in endothelia...Continue Reading

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Citations

Aug 4, 2012·International Journal of Medical Sciences·Wei-Xiu Zhao, Jian-Hua Lin
Dec 21, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Carly CumanEvdokia Dimitriadis
Jul 19, 2014·Journal of Molecular Histology·Michelle Van SinderenEvdokia Dimitriadis
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Oct 24, 2019·Journal of Cellular Physiology·Yuan YuanYan Cai
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