Distribution of NPY receptors in the hypothalamus

Neuropeptides
Serguei FetissovT Hökfelt

Abstract

Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the hypothalamic NPY receptors. In this review, we briefly summarize the origin of NPY and its two related peptides, peptide YY and pancreatic polypeptide in the hypothalamus. Moreover, based on the results obtained with histological techniques such as in situ hybridization, immunohistochemistry and ligand binding, we summarize data on the hypothalamic distribution of the known NPY receptors, the Y1 Y2, Y4 and Y5 receptors as best characterized to date. These NPY receptors are found with individual distribution patterns in many hypothalamic neurons including neuroendocrine motoneurons, magnocellular neurosecretory neurons and numerous neurons connecting the hypothalamus with the limbic and the autonomic nervous systems. The histochemical analyses allow characterization of coexisting molecules and in this way definition of the neurochemistry of NPY circuitries. By showing coexistence of various NPY receptors they provid...Continue Reading

References

Dec 14, 1992·Neuroscience Letters·J D Mikkelsen, P J Larsen
May 1, 1988·Regulatory Peptides·K Miyazaki, A Funakoshi
Dec 22, 1986·Regulatory Peptides·R EkmanP Panula
Nov 1, 1985·Brain Research Bulletin·M E HarringtonB Rusak
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J K McDonaldS M McCann
Aug 1, 1985·Neuroscience·B M ChronwallT L O'Donohue
Oct 1, 1985·Acta Physiologica Scandinavica·M BrooméL Terenius
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergB Hamberger
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K Tatemoto
Jul 12, 1996·The Journal of Biological Chemistry·D H WeinbergD J MacNeil
Apr 9, 1996·Regulatory Peptides·D Larhammar
Oct 18, 1996·The Journal of Biological Chemistry·Y HuM L McCaleb
Nov 1, 1996·The Journal of Biological Chemistry·M MatsumotoT Yamaguchi
Jun 1, 1997·Brain Research. Molecular Brain Research·E L GustafsonT A Branchek
Jun 20, 1997·Brain Research·D C WhitcombG E Hoffman
Oct 23, 1997·Brain Research. Molecular Brain Research·Y TongR Quirion
May 8, 1998·Neuropeptides·S Fetissov, S Nicolaïdis
May 8, 1998·Proceedings of the Society for Experimental Biology and Medicine·D R Gehlert
Jun 18, 1998·Annals of the New York Academy of Sciences·D LarhammarI Lundell
Sep 28, 1998·Brain Research. Molecular Brain Research·P J Larsen, P Kristensen
Oct 31, 1998·Brain Research. Molecular Brain Research·D JacquesR Quirion
Nov 5, 1998·Regulatory Peptides·C C Lee, R J Miller
Apr 2, 1999·The European Journal of Neuroscience·R M Parker, H Herzog

❮ Previous
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Citations

Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Sachin MoonatSubhash C Pandey
Nov 4, 2010·Cellular and Molecular Neurobiology·Erwan ThouennonYoussef Anouar
Oct 18, 2012·American Journal of Physiology. Endocrinology and Metabolism·Jennifer M RojasKevin D Niswender
Oct 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Udi E GhitzaYavin Shaham
May 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shinobu TakayasuJuro Sakai
Feb 8, 2011·Bioorganic & Medicinal Chemistry Letters·David A GriffithPhilip A Carpino
Jun 2, 2009·European Journal of Pharmacology·Satoshi MashikoAkio Kanatani
Jul 19, 2005·The Journal of Comparative Neurology·Pablo BrumovskyTomas Hökfelt
Jul 7, 2007·The European Journal of Neuroscience·Alessandra ObertoCarola Eva
Oct 8, 2015·Neuropeptides·R O TasanG Sperk
Dec 19, 2012·Epilepsia·Pablo M Casillas-EspinosaTerence J O'Brien
Feb 26, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Cornelia WaltherAnnette G Beck-Sickinger
Oct 16, 2013·The Journal of Comparative Neurology·Juan Pérez-FernándezManuel A Pombal
Dec 17, 2014·Neurobiology of Stress·Nicole M EnmanElisabeth J Van Bockstaele
Mar 29, 2011·Pharmacology & Therapeutics·Lei ZhangHerbert Herzog
Mar 1, 2012·Psychoneuroendocrinology·Frederico D GarciaSergueï O Fetissov
Jul 30, 2008·Nutrition·Melissa J S Chee, William F Colmers
Aug 30, 2008·Nutrition·Tomas HökfeltKarl H Pfenninger
Oct 3, 2006·Cell Metabolism·Sadaf Farooqi
Sep 18, 2012·Neuropeptides·Peter HolzerAitak Farzi
Jun 20, 2017·The Journal of Clinical Investigation·Zhigang ShiVirginia L Brooks
Sep 6, 2007·Endocrine Reviews·M M Kamiji, A Inui
Aug 19, 2011·American Journal of Physiology. Endocrinology and Metabolism·Annabelle Reaux-Le GoazigoCatherine Llorens-Cortes
Jul 5, 2019·Annals of the New York Academy of Sciences·Lucas B ComerasRamon O Tasan
Nov 6, 2010·Endocrine Reviews·Floor Remmers, Henriette A Delemarre-van de Waal
Oct 3, 2017·Frontiers in Physiology·Daniela GuarinoRosa Maria Bruno
May 22, 2021·Bone Research·Ruoyu ZhouXianghang Luo
Aug 29, 2006·Neuropeptides·Sarika Arora, Anubhuti

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