Distribution of omega-3 fatty acids in tissues of rabbits fed a flaxseed-supplemented diet

Metabolism: Clinical and Experimental
Bradley P AnderGrant N Pierce

Abstract

Diets rich in omega-3 polyunsaturated fatty acids are associated with decreased incidences of cardiovascular disease. The extent of incorporation and distribution of these beneficial fats into body tissues is uncertain. Rabbits were fed regular rabbit chow or a diet containing 10% ground flaxseed that is highly enriched with the omega-3 polyunsaturated fatty acid alpha-linolenic acid (ALA). The high-flaxseed diet resulted in an incorporation of ALA in all tissues, but mostly in the heart and liver with little in the brain. Docosahexaenoic and eicosapentaenoic acid levels were also selectively increased in some tissues, and the effects were not as large as ALA. Arachidonic acid and the ratio of omega-6/omega-3 fatty acids were decreased in all tissues obtained from the flax-supplemented group. Consumption of dietary flaxseed appears to be an effective means to increase ALA content in body tissues, but the degree will depend upon the tissues examined.

References

Jan 1, 1997·The Journal of Nutrition·S C Cunnane, M J Anderson
Sep 10, 2002·Trends in Biochemical Sciences·James G WallisJohn Browse
Sep 27, 2002·The British Journal of Nutrition·Graham C BurdgeStephen A Wootton
Sep 27, 2002·The British Journal of Nutrition·Graham C Burdge, Stephen A Wootton
Apr 7, 2005·Indian Journal of Pediatrics·Meharban Singh
Jul 18, 2006·The American Journal of Clinical Nutrition·Linda M ArterburnHarry Oken
Jul 18, 2006·The American Journal of Clinical Nutrition·Sharon R Akabas, Richard J Deckelbaum
Oct 19, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A P Simopoulos
Sep 27, 2007·Journal of Magnetic Resonance Imaging : JMRI·John A RonaldKem A Rogers
Sep 28, 2007·Investigative Ophthalmology & Visual Science·Hiroshi ToshidaAkira Murakami
Dec 7, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Stanley I RapoportMiki Igarashi
Jan 11, 2008·Retina·Sophie J BakriDebabrata Mukhopadhyay
Aug 12, 2008·Journal of the American College of Nutrition·J Alejandro AustriaGrant N Pierce
Feb 13, 2009·The Journal of Nutrition·Bianca M ArendtJohane P Allard

❮ Previous
Next ❯

Citations

May 3, 2016·The Journal of Nutritional Biochemistry·Riya GangulyGrant N Pierce
Apr 22, 2014·Experimental Gerontology·Stephanie P B CaligiuriGrant N Pierce
Mar 8, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Junjie ZhangChun Cai
Oct 4, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mihai D NiculescuCorneliu N Craciunescu
Oct 3, 2012·The Journal of Nutritional Biochemistry·Hemant PoudyalLindsay Brown
Mar 12, 2011·Meat Science·Antonella Dalle Zotte, Zsolt Szendro
Apr 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Andrew A FrancisGrant N Pierce
Jul 25, 2019·Animals : an Open Access Journal From MDPI·María RodríguezPilar G Rebollar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.