Distribution of origin of nitric oxide synthase-immunoreactive nerve fibers in the rat epididymis

Brain Research
N J DunU Förstermann

Abstract

Distribution of neuronal nitric oxide synthase-immunoreactive (nNOS-IR) nerve fibers and somata in the rat epididymis and major pelvic ganglia was studied by immunohistochemical methods. In the epididymis, the supply of nNOS-IR fibers was highest in the cauda and became progressively fewer toward the caput. In the cauda and corpus, nNOS-IR fibers were distributed throughout the subepithelial tissues and around the epithelial. The pattern of distribution of vasoactive intestinal polypeptide (VIP)- and tyrosine hydroxylase (TH)-immunoreactive fibers in the epididymis was similar but the latter was generally more numerous in a given region as compared to that of nNOS-IR fibers. A population of neurons in the major pelvic ganglia were nNOS-IR-, TH- or VIP-IR. Double-labeling studies revealed that few neurons in the major pelvic ganglia contained both nNOS-IR and TH-IR. Whereas nNOS-IR and VIP-IR appeared to co-localize in the same population of the pelvic ganglion cells. Similarly, nNOS-IR fibers in the epididymis were mostly VIP-positive and TH-negative. Unilateral injection of the fluorescent tracer Fluorogold into the junction between the vas deferens and the cauda labeled a population of neurons in the right and left major pelv...Continue Reading

References

Jul 17, 1992·Science·A L BurnettS H Snyder
Aug 31, 1992·Neuroscience Letters·J R Keast
Mar 1, 1982·The Tohoku Journal of Experimental Medicine·T ShimizuN J Dun

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Citations

Aug 17, 2005·The European Journal of Neuroscience·Yewlan Wanigasekara, Janet R Keast
Sep 13, 2018·Anatomical Science International·Yidan DaiShuang-Qin Yi

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