Distribution of p53, GST, and MTHFR polymorphisms and risk of cervical intraepithelial lesions in sicily

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Antonella AgodiSalvatore Travali

Abstract

Host factors, including genetic polymorphisms, may explain some of the individual differences in cervical cancer occurrence, and susceptibility information may be useful to address effective and specific preventive strategies for different countries. The purpose of the present study was to investigate the role of p53 codon 72, glutathione S-transferase class mu (GSTM1), glutathione S-transferase class theta (GSTT1), and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms on the risk for infection and/or of cervical intraepithelial lesions in women attending a colposcopy service in Catania, Sicily, with an already reported high prevalence of human papillomavirus. To identify the association among individual genetic polymorphisms, human papillomavirus infection, and histological findings, a case-control study was designed. Furthermore, to assess the combined effects of these polymorphisms on cervical cancer risk, combined genotype frequencies were compared among case patients and controls. Women homozygous for the p53 codon 72 Arg genotype were at a 5.6-fold higher risk for developing cervical intraepithelial neoplasia (CIN) 2 or 3 compared with those showing homozygosity for the Pro genotype or heterozygosity for the...Continue Reading

References

Apr 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·E K MalcolmM H Stoler
Jun 1, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·T AgorastosJ N Bontis
Aug 16, 2002·American Journal of Epidemiology·Julian LittleClarice Weinberg
Jan 22, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Guglielmo RoncoSilvia Franceschi
Feb 22, 2005·Gynecologic Oncology·Masatsugu UedaMinoru Ueki
Jul 14, 2005·Scandinavian Journal of Infectious Diseases·Mario RassuGiorgio Palu'
Aug 27, 2005·Cancer Detection and Prevention·Anita KoushikUNKNOWN Biomarkers of Cervical Cancer Risk (BCCR) Study Team
Oct 13, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Antonella AgodiSalvatore Travali

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Citations

Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Na Guo
May 29, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Zhen-Yong ZhangYao Xie
Sep 8, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Helmut von KeyserlingAndreas M Kaufmann
Jul 30, 2020·Medicina·Andrea Maugeri, Martina Barchitta
Mar 1, 2013·Journal of Cellular and Molecular Medicine·Anca BotezatuGabriela Anton
Oct 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Anita SharmaJoginder Kumar Sharma
Mar 17, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Sitakan NatphopsukTakafumi Ishida
May 12, 2012·Asian Pacific Journal of Tropical Medicine·Ying Liu, Liang-Zhi Xu
Mar 7, 2021·Journal of Personalized Medicine·Deborah TraversiStefania Boccia

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International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Antonella AgodiSalvatore Travali
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