PMID: 8971672Dec 1, 1996Paper

Distribution of penicillins into subcutaneous tissue chambers in ponies

Journal of Veterinary Pharmacology and Therapeutics
J M EnsinkJ J Tukker

Abstract

The distribution of penicillins into a tissue chamber implanted subcutaneously in ponies was studied. Ampicillin sodium (equivalent to 15 mg/kg ampicillin) was administered intravenously. Pivampicillin, a prodrug of ampicillin, was administered by nasogastric tube to fed ponies at a dose of 19.9 mg/kg (equivalent to 15 mg/kg ampicillin). Procaine penicillin G was administered intramuscularly at a dose of 12 mg/kg (equivalent to 12000 IU/kg). Six ponies were used for each medication. Antibiotic concentrations in plasma and tissue chamber fluid (TCF) were measured for 24 h after administration. Mean peak concentrations of ampicillin in TCF were 7.3 micrograms/mL, reached at 1.7 h, and 1.3 micrograms/mL, reached at 2.7 h, after administration of ampicillin sodium and pivampicillin respectively. The mean peak concentration of penicillin G of 0.3 microgram/mL was reached 12.3 h after administration of procaine penicillin G. Concentrations in TCF remained above the minimum inhibitory concentration of Streptococcus zooepidemicus for the proposed dosing intervals of 8, 12 and 24 h for ampicillin sodium, pivampicillin and procaine penicillin G respectively.

References

Sep 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·J M EnsinkA G Vulto
Dec 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·C R Clarke
Mar 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·R E BeadleC R Clarke
Sep 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·C R ClarkeE A Usenik
Mar 1, 1987·Equine Veterinary Journal·J D Baggot, J F Prescott
Sep 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·C R ShortC R Clarke
Mar 1, 1994·The British Veterinary Journal·P Sarasola, Q A McKellar

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Citations

Sep 6, 2002·Journal of Veterinary Pharmacology and Therapeutics·E van DuijkerenL A Meijer
Nov 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·M VoermansJ M Ensink
Jan 20, 2006·Journal of Veterinary Pharmacology and Therapeutics·G BoschJ M Ensink
Dec 18, 2002·Journal of Veterinary Pharmacology and Therapeutics·C GrekoJ Luthman
Nov 6, 2018·Journal of Veterinary Pharmacology and Therapeutics·Jarrod T YounkinMatthew Warner

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