Distribution of PGP 9.5, TH, NPY, SP and CGRP immunoreactive nerves in the rat and guinea pig atrioventricular valves and chordae tendineae

Journal of Anatomy
A AhmedJ Folan-Curran

Abstract

The distribution of nerves immunoreactive to protein gene product 9.5 (PGP 9.5), tyrosine hydroxylase (TH), neuropeptide Y (NPY), substance P (SP) and calcitonin gene related peptide (CGRP) antisera was investigated in the atrioventricular valves of the Sprague-Dawley rat and the Dunkin-Hartley guinea pig using confocal and epifluoresence microscopy. No major differences were noted between the innervation of the mitral and tricuspid valves in either species. For all antisera the staining was more extensive in the guinea pig valves. Two distinct nerve plexuses separated by a 'nearly nerve free' zone were identified in both species with each antiserum tested. This was most apparent on the anterior cusp of the mitral valve. The major nerve plexus extends from the atrioventricular ring through the basal, intermediate and distal zones of the valves towards the free edge of the valve cusp. These nerve bundles, arranged as primary, secondary and tertiary components, ramify to the free edge of the valve and extend to the attachment of the chordae. They do not contribute to the innervation of the chordae tendineae. The second, minor chordal plexus, runs from the papillary muscles through the chordae tendineae and passes parallel to the ...Continue Reading

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Citations

Jul 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Gaurav KrishnamurthyNeil B Ingels
Feb 2, 2010·American Journal of Veterinary Research·Geoff J CulshawBrendan M Corcoran
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Mar 24, 2015·Progress in Retinal and Eye Research·Ana Santos-CarvalhoCláudia Cavadas
Apr 14, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Akinobu ItohNeil B Ingels

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