Distribution of Phenolic Contents, Antidiabetic Potentials, Antihypertensive Properties, and Antioxidative Effects of Soursop (Annona muricata L.) Fruit Parts In Vitro

Biochemistry Research International
Stephen Adeniyi AdefeghaGaniyu Oboh

Abstract

Soursop fruit has been used in folklore for the management of type-2 diabetes and hypertension with limited information on the scientific backing. This study investigated the effects of aqueous extracts (1 : 100 w/v) of Soursop fruit part (pericarp, pulp, and seed) on key enzymes linked to type-2 diabetes (α-amylase and α-glucosidase) and hypertension [angiotensin-I converting enzyme (ACE)]. Radicals scavenging and Fe(2+) chelation abilities and reducing property as well as phenolic contents of the extracts were also determined. Our data revealed that the extracts inhibited α-amylase and α-glucosidase and ACE activities dose-dependently. The effective concentration of the extract causing 50% antioxidant activity (EC50) revealed that pericarp extract had the highest α-amylase (0.46 mg/mL), α-glucosidase (0.37 mg/mL), and ACE (0.03 mg/mL) inhibitory activities while the seed extract had the least [α-amylase (0.76 mg/mL); α-glucosidase (0.73 mg/mL); and ACE (0.20 mg/mL)]. Furthermore, the extracts scavenged radicals, reduced Fe(3+) to Fe(2+), and chelated Fe(2+). The phenolic contents in the extracts ranged from 85.65 to 560.21 mg/100 g. The enzymes inhibitory and antioxidants potentials of the extracts could be attributed to thei...Continue Reading

References

Jan 1, 1987·Free Radical Biology & Medicine·G Minotti, S D Aust
Jul 1, 1971·Biochemical Pharmacology·D W Cushman, H S Cheung
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Sep 8, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G L BakrisJ Sowers
Mar 7, 2002·Journal of Agricultural and Food Chemistry·Liangli YuMing Qian
Oct 31, 2002·Journal of Agricultural and Food Chemistry·Yi-Fang ChuRui Hai Liu
Jun 10, 2004·Journal of Agricultural and Food Chemistry·Alicia MarínMaría I Gil
Sep 1, 2006·Developmental Neuroscience·Hülya BayirValerian E Kagan
Nov 6, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Q-L LiG-L Zhang
Jan 26, 2011·Molecular Interventions·Ernesto L Schiffrin
Jan 7, 2015·Saudi Journal of Biological Sciences·Shaheena BanuShams Tabrez

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Citations

Jun 23, 2020·Journal of the Science of Food and Agriculture·Calister Wingang MakebeP Nisha
Dec 29, 2020·Journal of Ethnopharmacology·Emanuel L PeterCrispin Duncan Sesaazi
Aug 31, 2019·Food Research International·Maria Terezinha Santos Leite NetaNarendra Narain
Dec 9, 2020·Food Research International·María de la Luz Cádiz-GurreaAntonio Segura-Carretero

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Methods Mentioned

BETA
environmental stress

Software Mentioned

Graph Pad Prism

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