Distribution of potential cardiac sources of embolism in young and older stroke patients: implications for recurrent vascular events

Journal of Cardiovascular Medicine
S De CastroF Fedele

Abstract

Transesophageal echocardiography (TEE) has improved the diagnostic evaluation of ischemic stroke patients, permitting detection of potential cardiac sources of embolism. The present study aimed to evaluate the distribution of potential cardioembolic sources in young versus older stroke patients and their clinical implication for recurrent vascular events. Two hundred and twenty-eight patients with undetermined ischemic stroke were enrolled in the study. All patients were submitted to transthoracic and to TEE examination. The mean follow-up period was 43 +/- 19 months. The overall detection of cardiac sources of embolism was significantly higher in younger than in older patients (P = 0.006). Atrial septal abnormalities were more prevalent in the younger than in the older population (P = 0.006), whereas complicated aortic plaques were detected more often in older patients. During the follow-up period of 4-5 years, we identified 40 recurrent stroke episodes or vascular deaths. As expected, there was a significant difference in recurrent vascular events and death of older patients compared to the younger ones (P = 0.025). The present study demonstrates that atrial septal abnormalities and aortic atheromas are the most prevalent ech...Continue Reading

References

Sep 15, 1992·Annals of Internal Medicine·M Di TullioS Homma
Nov 1, 1991·Journal of the American College of Cardiology·A C PearsonA J Labovitz
Mar 21, 1991·The New England Journal of Medicine·A S Pearlman
Jul 15, 1990·The American Journal of Cardiology·P S Rahko, Q B Xu
Oct 1, 1990·American Heart Journal·R N Belkin, J Kisslo
May 5, 1988·The New England Journal of Medicine·P LechatY Grosgogeat
Jan 1, 1983·Stroke; a Journal of Cerebral Circulation·R G Hart, V T Miller
Jan 1, 1982·Ultrasound in Medicine & Biology·L S OngS S Barold
Dec 1, 1995·Journal of the American College of Cardiology·R S FreedbergI Kronzon
Dec 1, 1994·The New England Journal of Medicine·P AmarencoM G Bousser
Sep 15, 1994·The American Journal of Cardiology·E F JonesA M Tonkin
Feb 1, 1994·Stroke; a Journal of Cerebral Circulation·J BurnC Warlow
Sep 15, 1993·Annals of Internal Medicine·C StöllbergerR Karnik
Nov 22, 1997·Stroke; a Journal of Cerebral Circulation·J K RobertsS Homma
May 8, 2000·Stroke; a Journal of Cerebral Circulation·G W PettyD O Wiebers
Jun 7, 2000·Journal of the American College of Cardiology·S Sadanandan, M V Sherrid
Jun 10, 2000·Chest·K J NikulaC Hobbs
Oct 7, 2000·Stroke; a Journal of Cerebral Circulation·S De CastroN G Pandian
Nov 3, 2001·Stroke; a Journal of Cerebral Circulation·A J GrauH C Diener
Dec 12, 2001·Stroke; a Journal of Cerebral Circulation·W LalouschekUNKNOWN Vienna Stroke Study Group
Jun 5, 2002·Circulation·Jonathan L Halperin, Valentin Fuster
Dec 25, 2002·Cerebrovascular Diseases·Rosella MusolinoRaoul Di Perri
May 3, 2003·Journal of Clinical Epidemiology·Gosse de JongJan Lodder
Jul 10, 2003·Lancet Neurology·José M Ferro
Jan 1, 1995·Archives of Gerontology and Geriatrics·C Gambini, E Paciaroni

❮ Previous
Next ❯

Citations

Nov 30, 2007·The New England Journal of Medicine·Michael HandkeAnnette Geibel
May 21, 2010·Neurological Research·Qi BiZhe Song
Oct 30, 2010·The American Journal of Cardiology·Stefano De CastroDanilo Toni
Dec 3, 2014·American Heart Journal·Emer R McGrathMartin J O'Donnell
Aug 25, 2010·BMC Neurology·Akram A HosseiniHani T S Benamer
Jul 2, 2011·Journal of Cardiovascular Medicine·Antonello D'Andrea, Raffaele Calabrò
May 23, 2013·Journal of Cardiovascular Medicine·Pierre-Yves CourandEric Bonnefoy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.