Distribution of presenilin 1 and 2 and their relation to Notch receptors and ligands in human embryonic/foetal central nervous system

Brain Research. Developmental Brain Research
B KostyszynE Sundström

Abstract

Notch signaling in vertebrates is mediated by four Notch receptors (Notch-1, -2, -3, and -4) that are activated by interacting with at least five different Notch ligands, Jagged-1, Jagged-2, Delta-1, -2, and -3. Recent studies have shown that the gamma-secretase-like intramembranous cleavage of Notch receptors to release their cytoplasmic signaling domains requires the presenilin (PS) proteins 1 and 2 (PS1 and PS2). Here, we used immunohistochemistry to compare the distribution of all four Notch receptor proteins and three ligands in the context of co-localization with PS1 and PS2 in first trimester human central nervous system (CNS). In addition, we investigated Notch receptors and ligands expression by Western blotting. The study was performed on the forebrain and spinal cord of human embryonic/foetal CNS (5-11 gestational weeks). Results showed a divergent distribution of the different Notch receptor proteins with only Notch-1 being co-localized with PS1 and PS2. Notch-2 was only seen occasionally within the developing cortex and spinal cord. Notch-3 expression was restricted to neuroepithelial cells of the spinal cord and endothelial cells in blood vessels of both developing cerebral cortex and spinal cord. The weak, puncta...Continue Reading

References

Apr 1, 1995·Brain Research. Molecular Brain Research·M HiguchiY Tsujimoto
Mar 24, 1995·Cell·C E LindsellG Weinmaster
Mar 15, 1994·Genes & Development·P J SwiatekT Gridley
Jan 1, 1997·Molecular and Cellular Neurosciences·T Gridley
Mar 4, 1998·Annals of Neurology·N D MehtaM Hutton
May 30, 1998·Cell·G Struhl, A Adachi
Nov 20, 1998·Molecular and Cellular Biology·S JarriaultA Isra l
Jan 5, 1999·Science·H QiS Artavanis-Tsakonas
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·W J RayA M Goate
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·W SongB A Yankner
Dec 23, 1999·Current Biology : CB·B E BerechidJ S Nye
Jan 5, 2000·The Journal of Biological Chemistry·J J PalacinoB Wolozin
Aug 10, 2000·Nature Genetics·J Wei, G P Hemmings
Sep 28, 2000·Biochemical and Biophysical Research Communications·K ShimizuH Hirai
Oct 6, 2000·Journal of Neuroscience Research·M NakajimaT Shirasawa
Jan 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·G Struhl, I Greenwald
Apr 13, 2001·Neuroscience·B KostyszynE Sundström
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·T MizutaniT Honjo
Aug 17, 2001·Trends in Neurosciences·J Lundkvist, U Lendahl
Aug 24, 2001·The Journal of Biological Chemistry·M T SaxenaR Kopan
Oct 31, 2001·Neuron·R E Tanzi, L Bertram
Jan 5, 2002·The Journal of Biological Chemistry·Bridget E BerechidJeffrey S Nye
Feb 28, 2002·Biochemical and Biophysical Research Communications·Kiyoshi ShimizuHisamaru Hirai
May 7, 2002·Molecular Membrane Biology·M BaronM B Wilkin
May 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Keith Brennan, Philip Gardner
Jan 29, 2003·The Journal of Biological Chemistry·Takeshi Ikeuchi, Sangram S Sisodia
Feb 20, 2003·The Journal of Biological Chemistry·Christin E BlandMatthew D Rand
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Tatsuya IsoLarry Kedes

❮ Previous
Next ❯

Citations

Nov 30, 2004·Expert Opinion on Investigational Drugs·Craig W RitchieColin L Masters
Jan 19, 2008·Trends in Neurosciences·Matthew R SarkisianPasko Rakic
Oct 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Justin D LathiaCharles Ffrench-Constant
Dec 20, 2008·Journal of Neurochemistry·Justin D LathiaAiwu Cheng
May 21, 2014·Molecular and Cellular Biology·Arjan J GrootMarc Vooijs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.