PMID: 638173Mar 30, 1978Paper

Distribution of prostaglandin biosynthetic pathways in organs and tissues of the fetal lamb

Biochimica Et Biophysica Acta
C R Pace-Asciak, G Rangaraj

Abstract

Five prostaglandins, i.e. prostaglandins E2, F2alpha and D2, 6-keto-prostaglandin F1alpha and thromboxane B2, were measured by mass spectrometry. Homogenates of fetal lamb brain, lung, liver, spleen and kidney and the ductus arteriosus, aorta and pulmonary artery formed different amounts of each product. Although the main prostaglandin in the fetal organs was prostaglandin E2, arterial tissue formed mostly 6-keto-prostaglandin F1alpha. These results demonstrate significant differences between organs and tissues in the relative direction of the 'prostaglandin synthetase' enzyme complex.

References

May 1, 1977·Prostaglandins·C R Pace-Asciak
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·T MiyamotoO Hayaishi
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson

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Citations

Jan 1, 1980·Advances in Enzyme Regulation·I MahmudY Miura
Sep 1, 1982·Prostaglandins·C W LefflerR S Green
May 20, 1997·Brain Research. Developmental Brain Research·N KrunicF Coceani
Feb 1, 1981·Prostaglandins and Medicine·R V PanganamalaA J Merola
Jul 16, 2005·American Journal of Obstetrics and Gynecology·Jonathan J HirstDavid M Olson
Sep 14, 1999·The American Journal of Physiology·W B CaoP Biancani
Sep 14, 1979·Journal of Chromatography·F A FitzpatrickM Rigaud

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