Dec 1, 1975

Distribution of prostaglandin E 9-ketoreductase and NAD+-dependent and NADP+-dependent 15-hydroxyprostaglandin dehydrogenase in the renal cortex and medulla of various species

Research Communications in Chemical Pathology and Pharmacology
D KatzenL Levine

Abstract

Regional distributions of PGE 9-ketoreductase and 15-hydroxy-prostaglandin dehydrogenase were examined in the cytoplasmic fractions from the kidneys of seven species. All species contained an NADPH-dependent reductase, as well as NAD+- and NADP+-dependent dehydrogenases in both cortex and medulla. A previously unrecognized cytoplasmic NADH-dependent PGE 9-ketoreductase was also detected in the cortex and medulla of rat and bovine kidney. Total NAD+- and NADP+-dependent dehydrogenase activity was about equally distributed between the two renal regions of monkey, dog, rat, and swine. Bovine, rabbit, and cat had greater cortical than medullary dehydrogenase activity with ratios of 3, 5, and 10 respectively. The activities of NAD+- and NADP+-dependent dehydrogenase varied among the renal tissues.

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Mentioned in this Paper

Cortex Bone Disorders
Adrenal Cortex Diseases
Alcohol Oxidoreductases
Entire Cortex of Kidney
Entire Medulla Oblongata
Hydroxyprostaglandin Dehydrogenases
Bos taurus
NADH
Kidney
Medulla

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