The radiosensitivities of human tumor cell lines, grouped into 6 histological categories, have been studied using data from the published literature. The parameters alpha, beta, n, D0, D, and the surviving fraction to 2 Gy (S2) and 8 Gy (S8) were calculated. Only the two parameters mainly derived from the initial part of the survival curve, alpha and D, together with S2, provided data which were correlated with the clinical radioresponsiveness of each histological group. Thus, there are intracellular factors which influence clinical radioresponsiveness whose relative importance varies from one histological cell type to another. The value of D gave the most precise characterization of the average group radiosensitivity. It was possible to compare the in vivo radiosensitivities of non-severely hypoxic cells with those of tumor cells irradiated in vitro for 7 tumor lines grown as xenografts in mice. The average radiosensitivity was 1.9 times less in vivo than in vitro. This difference indicates that, in addition to the intrinsic factors of radioresistance demonstrated in vitro, and independently of severe hypoxia, there are other factors which specifically reduce radiosensitivity in vivo.
Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: analysis of 101 published survival curves
Perturbations in x-ray dose response in vitro with time after plating: a pitfall in the comparison of results obtained by different laboratories using asynchronous cell systems
Studies of variation in inherent sensitivities to radiation, 5-fluorouracil and methotrexate in a series of human and murine tumor cell lines in vitro
Establishment, characterization, and response to cytotoxic and radiation treatment of three human melanoma cell lines
Potential role for low dose limited-field radiation therapy (2 x 2 grays) in advanced low-grade non-Hodgkin's lymphomas
The effect of heterogeneity in tumor cell kinetics on radiation dose-response. An exploratory investigation of a plateau effect
Salvage extended-field irradiation in follicular non-Hodgkin's lymphoma after failure of chemotherapy
Tumor control probability for selective boosting of hypoxic subvolumes, including the effect of reoxygenation
Human papillomavirus E6 and E7 oncoproteins alter cell cycle progression but not radiosensitivity of carcinoma cells treated with low-dose-rate radiation
Effect of low-dose chest irradiation before chemotherapy on the rate of local failure in small-cell lung cancer
Expression of p53, p21/WAF/CIP, Bcl-2, Bax, Bcl-x, and Bak in radiation-induced apoptosis in testicular germ cell tumor lines
Photodynamic therapy resistant human colon carcinoma HT29 cells show cross-resistance to UVA but not UVC light
Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures.
Hemoglobin level significantly impacts the tumor cell survival fraction in humans after internal radiotherapy.
Radiobiological modeling of interplay between accelerated repopulation and altered fractionation schedules in head and neck cancer.
Hypoxia inducible factor (HIf1alpha and HIF2alpha) and carbonic anhydrase 9 (CA9) expression and response of head-neck cancer to hypofractionated and accelerated radiotherapy
Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments
The effect of patient-to-patient variability on the accuracy of predictive assays of tumor response to radiotherapy: a theoretical evaluation
Comparison between in vitro radiosensitivity and in vivo radioresponse in murine tumor cell lines. II: In vivo radioresponse following fractionated treatment and in vitro/in vivo correlations
The initial slope of human tumor cell survival curves: its modification by the oxic cell sensitizer beta-arabinofuranosyladenine.
Equivalent uniform dose concept evaluated by theoretical dose volume histograms for thoracic irradiation
Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells
Therapeutic application of CCK2R-targeting PP-F11: influence of particle range, activity and peptide amount
Residual γH2AX foci after ex vivo irradiation of patient samples with known tumour-type specific differences in radio-responsiveness
A preliminary assessment of whole-body radiotherapy interposed within a chemotherapy protocol for canine lymphoma
Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations
Linear energy transfer painting with proton therapy: a means of reducing radiation doses with equivalent clinical effectiveness
Hyperfractionated and hypofractionated radiation therapy for human malignant glioma xenograft in nude mice
Radiobiological aspects of continuous low dose-rate irradiation and fractionated high dose-rate irradiation
Radiobiological framework for the evaluation of stereotactic radiosurgery plans for invasive brain tumours
Radiation sensitivity and study of glutathione and related enzymes in human colorectal cancer cell lines
Intervals between multiple fractions per day. Differences between early and late radiation reactions
The RBE of fast neutrons for in vitro inactivation of human tumour cells determined by the ratio of mean inactivation doses
Carcinoma, Squamous Cell
Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.