Distribution of secretoneurin immunoreactivity in the spinal cord and lower brainstem in comparison with that of substance P and calcitonin gene-related peptide

The Journal of Comparative Neurology
J MarksteinerH Winkler

Abstract

Secretoneurin is a peptide of 33 amino acids generated in brain by proteolytic processing of secretogranin II. The distribution of this newly characterized peptide was investigated by means of immunocytochemistry and in situ hybridization in the spinal cord and lower brainstem of the rat. The staining pattern of secretoneurin immunoreactivity (IR) was compared to that of substance P (SP) and calcitonin gene-related peptide (CGRP) in adjacent sections. A high density of secretoneurin-IR fibers and terminals was found in lamina I and outer lamina II of the caudal trigeminal nucleus and of the spinal cord at all levels, around the central canal, and in the sympathetic and parasympathetic areas of the lateral cell columns. The ventral horn displayed a low to moderate density of secretoneurin-IR. The highest number of secretogranin II mRNA-containing cells was found in lamina II of the dorsal horn and in neurons of the dorsal root ganglia. In the white matter, secretoneurin-IR was most prominent in the dorsolateral part of the lateral funiculus and in the tract of Lissauer. The distributions of secretoneurin-IR and SP-IR were strikingly similar. CGRP-IR and secretoneurin-IR overlapped in the outer laminae of the dorsal horn, in the ...Continue Reading

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Citations

Jul 1, 1995·Histochemistry and Cell Biology·G SchürmannJ M Polak
Jan 1, 1996·Progress in Neurobiology·A J Lawrence, B Jarrott
Jan 30, 2002·Peptides·J J CollinsR E Papka
May 1, 1994·The European Journal of Neuroscience·R KirchmairA Saria
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Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Magnus KorsgrenLennart Greiff
Mar 6, 1995·The Journal of Comparative Neurology·J MarksteinerA Saria

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