Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms

Metallomics : Integrated Biometal Science
N V DolgovaIngrid J Pickering

Abstract

Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been conflicting reports upon human health benefits and detriments arising from consumption of selenium dietary supplements. Thus, early studies report a decrease in the incidence of certain types of cancer, whereas subsequent studies did not observe any anti-cancer effect, and adverse effects such as increased risks for type 2 diabetes have been reported. A possible contributing factor may be that different chemical forms of selenium were used in different studies. Using larval stage zebrafish (Danio rerio) as a model organism, we report a comparison of the toxicities and tissue selenium distributions of four different chemical forms of selenium. We find that the organic forms of selenium tested (Se-methyl-l-selenocysteine and l-selenomethionine) show considerably more toxicity than inorganic forms (selenite and selenate), and that this appears to be correlated with the level of bioaccumulation. Despite differences in concentrations, the tissue specific pattern of selenium accumulation was similar for the chemical forms tested; seleniu...Continue Reading

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Citations

Apr 12, 2016·Canadian Journal of Chemistry·Thomas Warner, Farideh Jalilehvand
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Jan 29, 2019·Metallomics : Integrated Biometal Science·Natalia V DolgovaIngrid J Pickering
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Jan 15, 2021·The Science of the Total Environment·Mohammad NaderiRaymond W M Kwong
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May 8, 2018·Biochimica Et Biophysica Acta. General Subjects·Natalia V DolgovaIngrid J Pickering
Aug 13, 2021·Environmental Science & Technology·Chantal M LanctôtWilliam W Bennett
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