Distribution of some activating KRAS and BRAF mutations in Slovene patients with colorectal cancer.

Medical Oncology
Alenka LicarSrdjan Novakovic

Abstract

Numerous clinical studies have shown that anti-EGFR therapies are effective only in a subset of patients with colorectal cancer. Even though mutations in the KRAS gene have been confirmed as negative predictors of the response to EGFR-targeted therapies, not all KRAS wild-type (wt-KRAS) patients will respond to treatment. Recent studies have demonstrated that additionally wild-type BRAF (wt-BRAF) genotype is required for response to panitumumab or cetuximab, suggesting that BRAF genotype criteria should be used together with KRAS genotype for selecting the patients who are about to benefit from the anti-EGFR therapy. In this study, 239 samples obtained from 215 patients with metastatic colorectal cancer were tested for the presence of the seven most common mutations in the KRAS gene and the V600E mutation in the BRAF gene. Among the tested patients, 53.8% of patients had wt-KRAS genotype and 46.2% were KRAS mutants. Around five percent (5.1%) of the tested patients bore the V600E mutation in BRAF gene. All the patients showing to have the V600E mutation in BRAF were wt-KRAS. The concordance of KRAS and BRAF mutational status between primary and metastatic tumor tissue samples was 100%. We have shown that the proportions of muta...Continue Reading

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Citations

Nov 1, 2017·Medical Oncology·Michał PędziwiatrAndrzej Budzyński
Nov 6, 2012·The International Journal of Biological Markers·Cristina BozzaoNicoletta Resta
Mar 7, 2021·Genes·Uršula Prosenc ZmrzljakAleksandra Nikolić

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