Distribution of stanniocalcin binding sites in the lamina terminalis of the rat

Brain Research
Srdjana RatkovicJohn Ciriello

Abstract

Stanniocalcin (STC-1), a 50 kDa glycoprotein hormone that regulates calcium/phosphate homeostasis in bony fish and mammals, has been shown to be expressed in central neurons and choroid plexus, and to exert a protective effect against hypercalcemic and hypoxic damage to neurons. Circumventricular organs are known to function in the regulation of ion and body fluid balance. Therefore, the possibility exists that STC-1 may be involved in the regulation of calcium/phosphate and fluid homeostasis through its actions on these central sites. In the present study, the distribution of STC-1 binding sites in forebrain circumventricular organs of the rat were investigated by in situ ligand binding using a stanniocalcin-alkaline phosphatase (STC-AP) fusion protein. Cells exhibiting STC-1 binding sites were found throughout the lamina terminalis. Dense cytoplasmic staining was observed predominantly within ependymal cells lining the anterior third ventricle region (AV3V), as well as cells of the choroid plexus. Additionally, neurons of the organum vasculosum of the lamina terminalis, the dorsal and ventral components of the median preoptic nucleus and the rostral aspects of the subfornical organ exhibited dense STC-1 cytoplasmic staining. ...Continue Reading

References

Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P M Gross, A Weindl
Sep 1, 1986·General and Comparative Endocrinology·Graham F WagnerD H Copp
Mar 1, 1994·Molecular and Cellular Endocrinology·Graham F Wagner, E Jaworski
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·H S OlsenGraham F Wagner
Aug 26, 1998·The American Journal of Pathology·K Z ZhangLeif C Andersson
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·Kerry HullS Harvey
Aug 18, 1999·Electrophoresis·R A WorthingtonJ A Barden
Feb 8, 2002·American Journal of Physiology. Renal Physiology·Kenichi Ishibashi, Masashi Imai
Mar 21, 2002·Clinical and Experimental Pharmacology & Physiology·M J McKinleyF A Mendelsohn
Feb 14, 2003·Journal of Neuroscience Research·Yan LongKeyi Yang
Mar 29, 2003·American Journal of Physiology. Heart and Circulatory Physiology·David Sheikh-HamadKeith Youker
Dec 23, 2003·Regulatory Peptides·G Trevor Cottrell, Alastair V Ferguson
Apr 6, 2004·Molecular and Cellular Endocrinology·Christopher R McCuddenGraham F Wagner
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Douglas A FittsJohn E Bassett
Oct 13, 2004·Peptides·Martina SerlachiusLeif C Andersson
Oct 13, 2004·Peptides·Yuji Yoshiko, Jane E Aubin
Aug 19, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gabriella B LundkvistGene D Block
Sep 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·Craig P HasiloGraham F Wagner
Dec 27, 2005·The Journal of Biological Chemistry·Shufang WuFrancesco De Luca
Mar 24, 2006·The European Journal of Neuroscience·Zizhen Zhang, Charles W Bourque
Jun 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Deenaz ZaidiGraham F Wagner
Aug 12, 2006·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Graham F Wagner, Gabriel DiMattia
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Johan A WestbergLeif C Andersson
Apr 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Keiichi KoizumiShinpei Nakazawa
Jul 31, 2007·Brain Research Reviews·Henri M Duvernoy, Pierre-Yves Risold
Aug 10, 2007·The European Journal of Neuroscience·Raúl Aguilar-RobleroMauricio Díaz-Muñoz
Aug 24, 2007·Journal of Neurophysiology·Ryoichi Teruyama, William E Armstrong
Sep 19, 2007·Journal of Biological Rhythms·Choon Kiat Sim, Daniel B Forger
Oct 25, 2007·Antioxidants & Redox Signaling·Miguel Angel García-BereguiaínCarlos Gutiérrez-Merino
Oct 30, 2007·Cerebral Cortex·Nicolas HeckHeiko J Luhmann
Jan 18, 2008·American Journal of Physiology. Renal Physiology·Olga SazonovaGraham F Wagner

Citations

Apr 5, 2012·ISRN Endocrinology·Timothy D J RichardsGraham F Wagner
Jun 15, 2010·Molecular and Cellular Endocrinology·Jeffrey TurnerGraham F Wagner
May 14, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pauline M Smith, Alastair V Ferguson
Aug 31, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason M MoreauJohn Ciriello

Related Concepts

Stc1 protein, rat
Autoradiography
Neoglycoproteins
Organum Vasculosum Laminae Terminalis
Subfornical Organ
Drug or Chemical Tissue Distribution
Rats, Wistar
Alkaline Phosphatase
Body Fluids
Calcium phosphate

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.