Distribution of surface protein variants among hyperinvasive meningococci: implications for vaccine design

Infection and Immunity
Rachel UrwinM C J Maiden

Abstract

The bacterium Neisseria meningitidis is a major cause of meningitis and septicemia worldwide. Outer membrane proteins (OMPs) are candidates in the search for comprehensive meningococcal vaccines; however, the formulation of OMP vaccines is complicated by antigenic diversity, which is generated by high levels of genetic reassortment and strong positive selection in the meningococcal antigen genes. The genetic and antigenic diversity of three OMPs (FetA, PorA, and PorB) among a global collection of meningococcal isolates representative of the major hyperinvasive clonal complexes was determined. There was evidence for antigenic structuring among the three OMPs that could not be explained purely by descent. These observations violated the predictions of the clonal and epidemic clonal models of population structure but were in concordance with models of strain structure which propose that host immunity selects for nonoverlapping antigen combinations. The patterns of antigenic variant combinations suggested that an OMP-based vaccine with as few as six PorA and five FetA variant sequences could generate homologous immune responses against all 78 isolates examined.

References

Jul 1, 1985·Reviews of Infectious Diseases·C E FraschJ T Poolman
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D A CaugantR K Selander
Aug 1, 1988·Infection and Immunity·D A CaugantR K Selander
Nov 1, 1972·The Journal of Infectious Diseases·F A WyleJ P Lowenthal
May 1, 1995·Clinical and Diagnostic Laboratory Immunology·E WedegeD A Caugant
Jun 1, 1993·The Journal of Infectious Diseases·J F WangM Achtman
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J M SmithB G Spratt
Jun 1, 1996·Molecular Biotechnology·R Staden
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·M C MaidenB G Spratt
Sep 25, 1998·Epidemiology and Infection·R UrwinA J Fox
May 5, 1999·JAMA : the Journal of the American Medical Association·J W TapperoB A Perkins
Apr 5, 2001·Trends in Microbiology·S Gupta, M C Maiden
Jun 1, 2001·Emerging Infectious Diseases·M AchtmanA E Platonov
Dec 26, 2001·Bioinformatics·S KumarM Nei
May 4, 2002·Lancet·Luis JódarDan M Granoff
Sep 25, 2002·Molecular Biology and Evolution·Rachel UrwinMartin C J Maiden
Jul 12, 2003·Microbiology·Emily A L ThompsonMartin C J Maiden
Oct 15, 2003·Trends in Microbiology·Rachel Urwin, Martin C J Maiden
Jun 18, 2004·Emerging Infectious Diseases·Joanne E RussellJanet Suker

❮ Previous
Next ❯

Citations

Nov 1, 2013·The Journal of Microbiology·Byeong-Jae LeeYoung Ki Choi
Feb 16, 2013·Journal of Proteome Research·Bas van de WaterbeemdAd P J M de Jong
May 25, 2010·Nature Genetics·Iñaki ComasSebastien Gagneux
May 14, 2008·Nature Reviews. Microbiology·Duccio MediniRino Rappuoli
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Caroline O BuckeeMartin C J Maiden
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Caroline O BuckeeSunetra Gupta
May 30, 2009·The Journal of Infectious Diseases·Odile B HarrisonIan M Feavers
Sep 2, 2011·The Journal of Infectious Diseases·Ana Belén Ibarz-PavónMartin C J Maiden
Apr 12, 2007·Journal of the Royal Society, Interface·Marc Lipsitch, Justin J O'Hagan
May 17, 2007·Proceedings. Biological Sciences·Caroline BuckeeSunetra Gupta
Feb 5, 2010·Proceedings. Biological Sciences·Caroline O BuckeeKeith A Jolley
Jul 8, 2010·Antimicrobial Agents and Chemotherapy·Muhamed-Kheir TahaIzabela Wasko
May 23, 2007·Antimicrobial Agents and Chemotherapy·Muhamed-Kheir TahaMaria Leticia Zarantonelli
Jan 19, 2006·Clinical Microbiology Reviews·Lee H Harrison
Jun 28, 2013·Clinical and Vaccine Immunology : CVI·Jay LucidarmeRay Borrow
Aug 24, 2006·Infection and Immunity·Martin J CallaghanMartin C J Maiden
Sep 14, 2012·Journal of Clinical Microbiology·Chivonne MoodleyUNKNOWN Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa
Nov 10, 2006·Journal of Clinical Microbiology·Johannes Elias, Ulrich Vogel
Feb 9, 2007·Journal of Clinical Microbiology·Jane W MarshLee H Harrison
Jan 5, 2006·Journal of Clinical Microbiology·Abdullah KilicYi-Wei Tang
Jun 16, 2006·Annual Review of Microbiology·Martin C J Maiden
Sep 22, 2011·Veterinary Research·Ellen Ariel
Jun 23, 2006·BMC Bioinformatics·Keith A Jolley, Martin C J Maiden
Oct 13, 2004·Retrovirology·Palle VillesenFinn Skou Pedersen
Mar 21, 2012·PloS One·Ivano de FilippisD Rebecca Prevots
Aug 27, 2013·PloS One·Wen ZhangKanglin Wan
Apr 25, 2009·PLoS Pathogens·Yogitha N SrikhantaMichael P Jennings
Mar 6, 2010·Emerging Infectious Diseases·Johannes EliasArie van der Ende
May 5, 2007·Journal of Molecular Evolution·Ted H M Mes, Jos P M van Putten
Dec 15, 2010·Seminars in Immunopathology·Can M UnalKristian Riesbeck

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.