PMID: 6981200Apr 1, 1982Paper

Distribution of T-cell subsets identified by monoclonal antibodies in cell suspensions from lymph node biopsies of human B-cell lymphomas

Scandinavian Journal of Haematology
S KvaløyT Godal

Abstract

The distribution of T-cell subsets has been examined in cell suspensions from lymph node biopsies from 37 non-Hodgkin lymphomas (NHL) of B-cell origin and 8 cases of Hodgkin's disease (HD). T-inducer/helper cells (T4+ cells) and T-suppressor/cytotoxic cells (T8+ cells) were identified by the monoclonal antibodies OKT4 and OKT8, respectively. Compared with reactive lymph nodes the T-cell subset distribution was aberrant in 18/37 (48.6%) of the B-cell lymphomas. The T-suppressor subset was dominating cells in 14/37 (37.8%) and the T-helper subset in 4/37 (10.8%) of the cases examined. In patients with leukaemic disease, a concordant T-cell subset distribution in lymph nodes and PBL was observed in 5 out of 6 cases. HLA-DR antigen was examined in a selected number of cases with a heteroantiserum. In general, the T-cells from neoplastic tissues expressed an increased percentage of HLA-DR antigen. This was most pronounced in cases with a dominance of T8+ cells, in which the majority of T8+ cells expressed HLA-DR antigen. These findings suggest that an increased proportion of activated T-suppressor cells are present in a proportion of B-cell lymphomas. Possible clinical and biological implications are discussed.

References

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Citations

Oct 1, 1987·American Journal of Hematology·A Janowska-WieczorekL M Pilarski
Feb 15, 1984·International Journal of Cancer. Journal International Du Cancer·S KvaløyT Godal
Jun 15, 1984·International Journal of Cancer. Journal International Du Cancer·C GattringerH Braunsteiner
Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·A Porwit-KsiazekP Biberfeld

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