Oct 15, 1989

Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues

The Journal of Immunology : Official Journal of the American Association of Immunologists
B FaliniE Ciccone


Frozen sections from normal and pathologic human tissues were immunostained by the APAAP technique with three mAb directed against different epitopes of the TCR gamma delta; TCR delta 1 which binds to all cells bearing the TCR gamma delta; BB3 and delta TCS1 which, by immunoprecipitation studies, appear to react respectively with the disulfide-linked and nondisulfide-linked form of the TCR gamma delta. In normal thymus, TCR delta 1+ cells accounted for approximately 2% of the CD3+ thymocytes and were about three times more numerous in the medulla than in the cortex. TCR delta 1+ cells were mostly constituted by the delta TCS1 reactive subset (average ratio delta TCS1/BB3: 3.7). In the tonsil, the TCR delta 1+ cells (about 3% of CD3+ elements) were mainly located in the interfollicular area, where they frequently tended to arrange around high endothelium venules. In most samples, TCR delta 1+ cells were distributed beneath to the tonsil epithelium. Unlike thymus, the majority of TCR delta 1+ cells were usually constituted by the BB3-reactive subset (average BB3/delta TCS1 ratio: 2.0). A similar predominance of BB3+ over delta TCS1+ cells was also observed in normal peripheral blood. The spleen was the organ with the highest conc...Continue Reading

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Mentioned in this Paper

Monoclonal Antibodies
Cortex Bone Disorders
Adrenal Cortex Diseases
Peripheral Blood
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Entire Medulla Oblongata
Neoplasm of Uncertain or Unknown Behavior of Thymus

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