PMID: 6978728Apr 1, 1982Paper

Distribution of T-lymphocyte subsets in Hodgkin's disease characterized by monoclonal antibodies

British Journal of Cancer
M S DorreenT A Lister

Abstract

Mononuclear-cell suspensions of lymph nodes, spleen and blood from 24 patients with active Hodgkin's disease (HD) were studied for possible imbalance of T and B lymphocytes, and T-lymphocyte subsets, using monospecific anti-T antibodies and other reagents. A profile showing T-cell predominance was demonstrated in lymph nodes and blood, with total T-cells ranging from 50-70% of the cell count. As defined by monoclonal antibodies, 70-85 of the latter comprised the "inducer" subclass, the remainder being "suppressor" cells. There were no essential differences between histologically involved and uninvolved lymph nodes from HD patients, though total T-cell proportions were lower in "normal lymph node" controls. The profiles of spleens electively removed, as part of pre-treatment staging procedures, showed reduced total T-cell numbers, whether these were involved with HD or not. These differences are accounted for principally by fewer T "inducer" cells (24%, in spleen, v. 54% in involved lymph nodes and 47% in "normal" control nodes). Possible explanations for these findings are discussed. Our results demonstrate similar profiles in histologically diseased and normal tissue, rather than any clear imbalance of T-cell proportions which...Continue Reading

Citations

Mar 1, 1988·The Japanese Journal of Surgery·T AkiyoshiH Tsuji
Oct 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·H MurakamiH Omura
Oct 1, 1989·American Journal of Hematology·S M FesusJ Manning
Jun 20, 2018·Frontiers in Oncology·Christoph Renner, Frank Stenner
Jun 15, 1984·International Journal of Cancer. Journal International Du Cancer·C GattringerH Braunsteiner
Jul 1, 1984·Journal of Clinical Pathology·C S Morris, A E Stuart
Sep 1, 1985·Journal of Clinical Pathology·G SangsterM J Leyland

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