Distribution of the feline calicivirus receptor junctional adhesion molecule a in feline tissues

Veterinary Pathology
Patricia A PesaventoJ S Parker

Abstract

Junctional adhesion molecule A (JAM-A) is an immunoglobulin superfamily protein that plays an important role in the assembly and maintenance of tight junctions and the establishment of epithelial cell polarity. The feline JAM-A (fJAM-A) is a functional receptor for feline calicivirus (FCV). Among natural diseases associated with FCV infection, isolates that cause oral vesicular disease are detected in epithelial cells; however, isolates that cause systemic disease are detected in multiple cell types. The distribution of an FCV receptor or receptors in feline tissues is relevant to viral pathogenesis in that it should reflect the wide latitude of clinical sequelae associated with FCV infection. The authors examined the expression of feline JAM-A in the cat by using confocal immunofluorescence localization on normal tissues, with special regard to tissue targets of naturally occurring FCV. As described in the human and the mouse, fJAM-A was widely distributed in feline tissues, where it localized at cell-cell junctions of epithelial and endothelial cells. fJAM-A was highly expressed on feline platelets, with lower levels of expression on feline peripheral blood leukocytes. Additionally, FCV infection of a feline epithelial cell m...Continue Reading

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Dec 24, 2008·Journal of Virological Methods·Patricia PesaventoJohn S L Parker
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Citations

Dec 30, 2015·Viruses·Vera KempDiana J M van den Wollenberg
Mar 4, 2014·The Veterinary Clinics of North America. Small Animal Practice·Jane E Sykes
May 27, 2014·The Veterinary Journal·J M Monné RodriguezA Kipar
Oct 22, 2019·Frontiers in Immunology·Yoatzin Peñaflor-TéllezAna Lorena Gutiérrez-Escolano

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Methods Mentioned

BETA
flow cytometry

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Adobe Photoshop

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