Abstract
Junctional adhesion molecule A (JAM-A) is an immunoglobulin superfamily protein that plays an important role in the assembly and maintenance of tight junctions and the establishment of epithelial cell polarity. The feline JAM-A (fJAM-A) is a functional receptor for feline calicivirus (FCV). Among natural diseases associated with FCV infection, isolates that cause oral vesicular disease are detected in epithelial cells; however, isolates that cause systemic disease are detected in multiple cell types. The distribution of an FCV receptor or receptors in feline tissues is relevant to viral pathogenesis in that it should reflect the wide latitude of clinical sequelae associated with FCV infection. The authors examined the expression of feline JAM-A in the cat by using confocal immunofluorescence localization on normal tissues, with special regard to tissue targets of naturally occurring FCV. As described in the human and the mouse, fJAM-A was widely distributed in feline tissues, where it localized at cell-cell junctions of epithelial and endothelial cells. fJAM-A was highly expressed on feline platelets, with lower levels of expression on feline peripheral blood leukocytes. Additionally, FCV infection of a feline epithelial cell m...Continue Reading
References
Jun 1, 1992·Veterinary Microbiology·M Mochizuki
Jul 14, 1998·The Journal of Cell Biology·I Martìn-PaduraE Dejana
Nov 2, 1999·The Journal of Experimental Medicine·A Del MaschioE Dejana
Mar 4, 2000·Molecular Immunology·L A WilliamsD L Simmons
Nov 22, 2000·IUBMB Life·S K GuptaE H Ohlstein
Mar 10, 2001·Cell·E S BartonT S Dermody
Jan 29, 2002·Nature Immunology·Georg OstermannChristian Weber
Sep 26, 2002·Cell·Robert W WaltersMichael J Welsh
May 17, 2003·Blood·Meghna U NaikUlhas P Naik
Jul 3, 2003·Virus Research·Stanislav V SosnovtsevKim Y Green
May 11, 2004·Veterinary Pathology·P A PesaventoK F Hurley
Sep 4, 2004·Journal of Receptor and Signal Transduction Research·Malgorzata B SobockaElizabeth Kornecki
Jan 29, 2005·The Journal of Biological Chemistry·Kenneth J MandellCharles A Parkos
Apr 14, 2006·Journal of Virology·Akiko MakinoHiroomi Akashi
Aug 17, 2006·Veterinary Microbiology·Karen P CoyneRosalind M Gaskell
May 26, 2007·Nature Reviews. Immunology·Christian WeberElisabetta Dejana
Oct 5, 2007·Journal of Virology·Robert J Ossiboff, John S L Parker
Nov 8, 2007·Blood·Yasuyoshi SuganoAtsushi Miyajima
Apr 3, 2008·Cancer Research·Meghna U NaikUlhas P Naik
Nov 20, 2008·The FEBS Journal·Qiurong LiJieshou Li
Dec 9, 2008·Biochimica Et Biophysica Acta·Julian A Guttman, B Brett Finlay
Dec 24, 2008·Journal of Virological Methods·Patricia PesaventoJohn S L Parker
Jun 18, 2009·International Journal of Cancer. Journal International Du Cancer·Elaine A McSherryWilliam M Gallagher
Citations
Dec 30, 2015·Viruses·Vera KempDiana J M van den Wollenberg
Mar 4, 2014·The Veterinary Clinics of North America. Small Animal Practice·Jane E Sykes
May 27, 2014·The Veterinary Journal·J M Monné RodriguezA Kipar
Aug 17, 2016·Veterinary Microbiology·Jin TianLiandong Qu
Feb 3, 2015·Polish Journal of Veterinary Sciences·T Maślanka
Feb 3, 2015·Polish Journal of Veterinary Sciences·T Maślanka
Oct 22, 2019·Frontiers in Immunology·Yoatzin Peñaflor-TéllezAna Lorena Gutiérrez-Escolano
Feb 23, 2021·Frontiers in Veterinary Science·Christa Y HeywardTracy Stokol
Jul 10, 2021·Archives of Virology·Zhaoyang WangHong Jia
Aug 29, 2021·Viruses·Andrea M SpiriRegina Hofmann-Lehmann