PMID: 8601689Apr 1, 1996Paper

Distribution of the large aggregating proteoglycan versican in adult human tissues

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
B Bode-LesniewskaD R Zimmermann

Abstract

We studied the distribution of the large hyaluronan-binding proteoglycan versican (also known as PG-M) in human adult tissues using affinity-purified polyclonal antibodies that recognize the core protein of the prominent versican splice variants VO and V1. Versican was present in the loose connective tissues of various organs and was often associated with the elastic fiber network. Furthermore, it was localized in most smooth muscle tissues and in fibrous and elastic cartilage. Versican staining was also noted in the central and peripheral nervous system, in the basal layer of the epidermis, and on the luminal surface of some glandular epithelia. In blood vessels, versican was present in all three wall layers of veins and elastic arteries. In muscular arteries the immunoreactivity was normally restricted to the tunica adventitia. However, it appeared in the media and the split elastica interna of atherosclerotically transformed vessel walls. Our survey of the distribution of versican in normal human tissues now forms the basis for extended studies of potentially aberrant versican expression during pathogenic processes.

Citations

Feb 18, 1999·Journal of Cellular Biochemistry·B L YangB B Yang
Mar 25, 2000·Journal of Cellular Biochemistry·Y ZhangB B Yang
Sep 28, 2005·Histochemistry and Cell Biology·Naoko ToriyaItaru Mizoguchi
Mar 29, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Robert SztrolovicsPeter J Roughley
Feb 27, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·A C Erickson, J R Couchman
Jun 29, 2012·European Journal of Human Genetics : EJHG·Barbara Kloeckener-GruissemWolfgang Berger
Dec 6, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thomas AignerAntonio G Nascimento
Apr 12, 2011·Tissue Engineering. Part B, Reviews·Jennifer Y C ChengLaura Poole-Warren
Oct 16, 2010·Glycobiology·David A CarrinoArnold I Caplan
Jun 23, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shiwori OsadaYasuhiko Tomino
Jun 29, 2004·Journal of Clinical Pathology·M J PukkilaV-M Kosma
Oct 6, 1998·Annual Review of Biochemistry·R V Iozzo
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·N VenkatesanM S Ludwig
Jul 31, 2007·Breast Cancer Research : BCR·Albert J M YeeBurton Yang
Mar 18, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yineng FuThomas N Wight
Dec 7, 2007·American Journal of Veterinary Research·María-José DocampoAnna Bassols
Nov 26, 2013·European Journal of Medical Genetics·Gulab Sher, Muhammad Naeem
Apr 1, 2014·Fibrogenesis & Tissue Repair·Federica GenovesePeter Boor
Jan 6, 2000·Archives of Biochemistry and Biophysics·D A CarrinoA I Caplan
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·J KishimotoR E Burgeson
Nov 13, 2002·Current Rheumatology Reports·Yiping ZhangA Robin Poole
Jul 16, 2005·Current Eye Research·Takahisa KogaHidenobu Tanihara
Aug 14, 2015·International Journal of Cancer. Journal International Du Cancer·Kanda FanhchaksaiHideto Watanabe
Dec 19, 2001·Journal of Cellular Physiology·H Kresse, E Schönherr
Sep 25, 2003·International Journal of Cancer. Journal International Du Cancer·Kirsi VoutilainenVeli-Matti Kosma
Jan 12, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Terence N BukongPaul J Winwood
Aug 8, 2009·International Journal of Experimental Pathology·Daniele Lisboa RibeiroRejane Maira Góes
Oct 28, 2003·The Journal of Dermatology·Yoshihiro NomuraMasafumi Tsujimoto
Dec 11, 2007·Scandinavian Journal of Medicine & Science in Sports·A ScottK M Khan

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.