Distribution of the pores of epithelial basement membrane in the rat small intestine

The Journal of Veterinary Medical Science
Takashi Takeuchi, Tatsuo Gonda

Abstract

The distribution and diameter of the pores of epithelial basement membrane in the intestinal villi and the lymph nodules of ileal Peyer's patches were investigated in the rat small intestine by scanning electron microscopy after the removal of the overlying epithelial cells with OsO(4) maceration. In the duodenum, jejunum and ileum, the pores were mainly distributed at the upper three fourths of the villi, but were scarce around the top of the villi. The diameter of some of the pores in the upper three fourths of the villi was larger than that of those in the lower portion. The protrusion of lymphocytes and the cytoplasmic processes of macrophages were also seen at the orifices of the pores. In ileal Peyer's patches, in contrast, pores were densely distributed in the lower one third of the follicle-associated epithelium (FAE) where M cells were mainly seen. Furthermore, these pores were larger than those found in the upper two thirds. Lymphocytes or cytoplasmic processes of macrophages were frequently seen in the lower one third of FAE. These results suggest that the pores at the basement membrane correspond to the passage of the immunocompetent cells which are in contact with M cells or villous columnar epithelial cells and th...Continue Reading

References

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Citations

Dec 29, 2010·International Journal of Inflammation·Camille JungFrédérick Barreau
Feb 11, 2014·Drug Discovery Today·Yu Long HanFeng Xu
Oct 24, 2006·Annals of the New York Academy of Sciences·Elisabet Gullberg, Johan D Söderholm
Apr 24, 2012·Biomaterials·Mehdi NikkhahAli Khademhosseini
Apr 15, 2014·Cell Adhesion & Migration·Alexandros GlentisDanijela Matic Vignjevic
Mar 23, 2019·International Journal of Molecular Sciences·Judith RadloffSalah Amasheh
Jan 12, 2021·Immunogenetics·Håvard Bjørgen, Erling Olaf Koppang
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Federico CorreaPaolo Trevisi

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