PMID: 8606162Apr 1, 1996Paper

Distribution of the rol gene encoding the regulator of lipopolysaccharide O-chain length in Escherichia coli and its influence on the expression of group I capsular K antigens

Journal of Bacteriology
C DodgsonC Whitfield

Abstract

The rol (cld) gene encodes a protein involved in the expression of lipopolysaccharides in some members of the family Enterobacteriaceae. Rol interacts with one or more components of Rfc-dependent O-antigen biosynthetic complexes to regulate the chain length of lipopolysaccharide O antigens. The Rfc-Rol-dependent pathway for O-antigen synthesis is found in strains with heteropolysaccharide O antigens, and, consistent with this association, rol-homologous sequences were detected in chromosomal DNAs from 17 different serotypes with heteropolysaccharide O antigens. Homopolymer O antigens are synthesized by a pathway that does not involve either Rfc or Rol. It was therefore unexpected when a survey of Escherichia coli strains possessing mannose homopolymer O8 and O9 antigens showed that some strains contained rol. All 11 rol-positive strains coexpressed a group IB capsular K antigen with the O8 or O9 antigen. In contrast, 12 rol-negative strains all produced group IA K antigens in addition to the homopolymer O antigen. Previous research from this and other laboratories has shown that portions of the group I K antigens are attached to lipopolysaccharide lipid A-core, in a form that we have designated K(LPS). By constructing a hybrid ...Continue Reading

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Citations

Jun 8, 2006·Annual Review of Biochemistry·Chris Whitfield
Mar 2, 2016·FEMS Microbiology Reviews·Ivan MijakovicKürşad Turgay
Dec 1, 2009·Expert Review of Vaccines·Valentina A Feodorova, Michael J Corbel
Apr 14, 1999·Molecular Microbiology·C Whitfield, I S Roberts
Jan 22, 2003·Environmental Microbiology·Craig DanielsJoseph S Lam
Apr 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael WackerMarkus Aebi
Jul 21, 2005·Journal of Bacteriology·Adi PelegIlan Rosenshine
Apr 24, 2007·Applied and Environmental Microbiology·Hanna Dams-Kozlowska, David L Kaplan
Feb 2, 2008·Applied Microbiology and Biotechnology·Hanna Dams-KozlowskaDavid L Kaplan
Sep 17, 2008·Applied Microbiology and Biotechnology·Hanna Dams-KozlowskaDavid L Kaplan
Aug 1, 2009·EcoSal Plus·Chris Whitfield
Sep 8, 1999·Microbiology and Molecular Biology Reviews : MMBR·H L RocchettaJ S Lam
Mar 1, 1997·Journal of Bacteriology·L L BurrowsJ S Lam
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·M K Berlyn
Jul 18, 2021·Nature Communications·Yun YangJames H Naismith

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