Distribution of the UV filter 3-benzylidene camphor in rat following topical application

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Tue SøeborgBent Halling-Sørensen

Abstract

A straightforward analytical method for determination of 3-benzylidene camphor (3-BC) in rat adipose tissue, brain, liver, muscle, plasma and testis following topical application was developed and validated. Three exposure levels (60, 180 and 540 mg kg(-1) day(-1)) were tested for 65 days in male Sprague-Dawley rats (24 days postnatal). Sample preparation involving homogenization and n-heptane or methanol extraction of the tissue was applied before injection into the LC-ESI-MS-MS system. The response was linear from 2 to 100 microg l(-1) for the qualifier and the quantifier MRM transitions (R(2) (quantifier) > 0.994). Detection limit of the method corresponded to 0.005 microg g(-1) tissue and 12.5 microg l(-1) plasma, respectively. Recovery was determined for all tissues (adipose tissue: 40%; all other tissues: 80-100%) at three individual levels. 3-(4-Methyl benzylidene camphor) (4-MBC) was used throughout the study as internal standard. 3-Benzylidene camphor was detected in all tissues at all exposure levels at concentrations between 0.05 microg g(-1) (liver) and 36 microg g(-1) (adipose tissue) and in plasma at 16-89 microg l(-1). The method allowed for the quantification of 3-benzylidene camphor in all tested tissues follow...Continue Reading

References

Dec 31, 2002·Brain Research. Brain Research Reviews·Atsushi Takeda
Apr 6, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Vikram SarveiyaHeather A E Benson
Oct 2, 2004·Toxicology·Margret SchlumpfWalter Lichtensteiger

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Citations

Sep 22, 2009·Analytical and Bioanalytical Chemistry·Rosario RodilMechthild Schmitt-Jansen
Dec 14, 2011·Natural Product Research·Celine CouteauLaurence J M Coiffard
Apr 10, 2012·Annales de dermatologie et de vénéréologie·J-C Beani
Mar 12, 2016·Neurotoxicology·Żaneta BroniowskaBogusława Budziszewska
May 15, 2007·Toxicology·Tue SøeborgBent Halling-Sørensen
May 23, 2012·International Journal of Andrology·M KrauseK T Drzewiecki
Feb 20, 2015·Environmental Science and Pollution Research International·Ping GongHongjing Li
Dec 3, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E WielogórskaL Connolly
Dec 17, 2014·The Journal of Emergency Medicine·Cynthia D Santos, Jennifer C Cabot
Aug 17, 2016·International Journal of Environmental Research and Public Health·Jiaying WangShulin Zhuang
Sep 18, 2016·International Journal of Hygiene and Environmental Health·Hanne FrederiksenAnna-Maria Andersson
Nov 30, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Tue SøeborgAnna-Maria Andersson

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