Distribution of the vasoconstrictor and vasorelaxant effects of norbormide along the vascular tree of the rat

Life Sciences
Maurizio CavalliSergio Bova

Abstract

Norbormide is a vasoconstrictor of rat peripheral arteries and a relaxant in rat aorta. To characterise norbormide actions within the rat vascular tree we have investigated its effects on the contractile function of rings from several arteries and veins. A maximal norbormide concentration (50 microM) failed to contract thoracic aorta and carotid artery, whereas in pulmonary artery, abdominal aorta, iliac, caudal, and femoral arteries it induced a contractile effect that was respectively 4.8 +/- 0.6, 18.4 +/- 1.5, 39 +/- 5, 144 +/- 7, and 260 +/- 22% of that induced by 90 mM KCl. In pulmonary, carotid, and iliac arteries, and in thoracic and abdominal aorta, 50 microM norbormide inhibited KCl-induced responses. Norbormide (50 microM) contracted all veins investigated. The effect, expressed as % of KCl-induced contraction, was 121 +/- 25, 154 +/- 14.5, 154 +/- 18.2, 203 +/- 19, and 267 +/- 33 for pulmonary vein, thoracic and abdominal vena cava, iliac and jugular veins, respectively. In jugular vein, as previously shown in rat caudal artery, norbormide contraction was abolished in Ca2+-free medium, was unaffected by the Ca2+ channel blocker nifedipine, and was relaxed by SK&F 96365, a blocker of store-operated Ca2+ channels. i) r...Continue Reading

References

Jul 1, 1966·Journal of Medicinal Chemistry·G I PoosA P Roszkowski
Jun 12, 2003·European Journal of Pharmacology·Sergio BovaFabio Fusi
Apr 24, 1964·Science·A P ROSZKOWSKIR J MOHRBACHER

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Citations

Jul 1, 2009·Environmental Toxicology and Pharmacology·Shanthinie RavindranMalcolm Tingle
Jan 1, 2009·Environmental Toxicology and Pharmacology·Shanthinie RavindranMalcolm Tingle
Oct 11, 2016·Frontiers in Pharmacology·Claudio D'AmoreSergio Bova

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