PMID: 2510091Sep 11, 1989Paper

Distribution of thyrotropin-releasing hormone (TRH) in the hippocampal formation as determined by radioimmunoassay

Neuroscience Letters
W C LowM J Kubek

Abstract

The distribution of thyrotropin-releasing hormone (TRH) in the hippocampal formation was determined using a radioimmunoassay (RIA) specific for TRH. RIA of hippocampal subregions revealed that the CA3 region of the hippocampal formation contained the highest amount of TRH, followed by intermediate levels in region CA1 and the dentate gyrus. The hilus and subiculum contained the lowest levels. The issue of whether hippocampal TRH is derived from extrinsic and/or intrinsic sources was evaluated by making lesions of the major subcortical afferent to the hippocampus, the fornix pathway. Analysis of the hippocampal formation by RIA revealed that the ventral hippocampus contains higher levels of TRH than the dorsal hippocampus (6.01 +/- 0.62 pg/mg tissue weight vs 1.11 +/- 0.19 pg/mg tissue weight). Lesions of the fornix produced significant decreases in ventral TRH to 52.9% of its control level and in dorsal TRH to 28.8% of its control level. The results from these studies suggest that (1) there is a differential distribution of TRH in the hippocampal formation, (2) the hippocampal formation might be composed of extrinsic and intrinsic sources of TRH, and (3) extrinsic sources of TRH might enter the hippocampus via the fornix pathwa...Continue Reading

References

Jan 1, 1979·Acta Physiologica Scandinavica·H WigströmP Andersen
Jan 15, 1973·The Journal of Comparative Neurology·A Hjorth-Simonsen
Jul 19, 1974·Science·M J BrownsteinR D Utiger
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Nov 6, 1969·Biochemical and Biophysical Research Communications·J BolerA V Schally

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Citations

May 1, 1992·Neurochemical Research·A SattinJ R Simon
Jan 29, 2000·Biulleten' eksperimental'noĭ biologii i meditsiny·A N ChepkovaV G Skrebitskiĭ
Mar 18, 1999·Pharmacology, Biochemistry, and Behavior·A SattinR L Lloyd
Jun 1, 1996·The European Journal of Neuroscience·M Atzori, A Nistri
Sep 23, 2006·The Journal of Physiology·Pan-Yue DengSaobo Lei
Dec 7, 2019·Cellular and Molecular Neurobiology·Stephanie DauthKlaudia Brix

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