Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary

The Journal of Comparative Neurology
Christian A KellJ H Stehle

Abstract

In morphogenetic dynamics of neurons, and in adaptive physiology of brain function, transcription factors of the cyclicAMP signaling pathway, such as activator cyclicAMP responsive element binding protein (CREB) and inhibitor inducible cyclicAMP early repressor (ICER), play an important role. In particular, the presence of the transcription factor ICER in neurons or neuroendocrine cells suggests the need for the gating of an up-regulated gene expression. Little is known, however, about the natural distribution of the inhibitory transcription factor ICER. We, therefore, mapped the rodent brain and pituitary for an ICER immunoreaction and found a nuclear staining for this transcription factor. ICER-positive glial cells were found throughout the brain. ICER-positive neurons were found in sensory input centers, like the olfactory bulb, or sensory brain stem nuclei, and in hypothalamic nuclei involved in central neuroendocrine control. In addition, neuroendocrine/endocrine transducers, like the pituitary and the pineal gland showed a high basal presence of ICER. Our data show that a basic ICER level is required by many cell systems and can be seen as an anticipatory and/or a protective measure in systems with superior reactive dynam...Continue Reading

References

Aug 1, 1988·The Journal of Comparative Neurology·E T Cunningham, P E Sawchenko
Apr 15, 1986·The Journal of Comparative Neurology·R B Simerly, L W Swanson
Jan 1, 1983·Molecular and Cellular Biochemistry·J M Masserano, N Weiner
Sep 20, 1983·The Journal of Comparative Neurology·D van der Kooy, L Y Koda
Jul 1, 1995·Journal of Neurobiology·R von Bernhardi, K J Muller
Apr 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·Y TokitaP J Mulrow
Jun 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·K MuraseK Hayashi
Dec 28, 1995·Brain Research. Molecular Brain Research·S M Luckman, H J Cox
Sep 29, 1998·International Review of Cytology·W WittkowskiT M Böckers
Jun 11, 1999·The Journal of Biological Chemistry·K ObrietanD R Storm
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·B Mayr, M Montminy

❮ Previous
Next ❯

Citations

May 13, 2009·Molecular Neurobiology·Gilyana Borlikova, Shogo Endo
Jun 7, 2005·Neuroscience Letters·William J SchwartzPaolo Sassone-Corsi
Mar 29, 2014·Journal of Diabetes Research·Roberto Salvi, Amar Abderrahmani
Feb 28, 2013·The Journal of Biological Chemistry·Uršula Prosenc ZmrzljakDamjana Rozman
Mar 27, 2007·General and Comparative Endocrinology·Meng Yao, Robert J Denver
Jul 20, 2005·Annals of Medicine·Christian A Kell, Jörg H Stehle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.