Distribution of trkB tyrosine kinase immunoreactivity in the rat central nervous system

Brain Research
X F ZhouR A Rush

Abstract

Recent evidence suggests that trkB tyrosine kinase is a high affinity receptor for brain-derived neurotrophic factor (BDNF). BDNF can act as a survival factor for several neuronal subgroups and its mRNA is distributed widely throughout the central nervous system. However, the functional targets of BDNF are poorly defined. We have used immunochemical and immunohistochemical techniques to determine the regional distribution and cellular localization of trkB tyrosine kinase-like immunoreactivity. The staining pattern indicates that the trkB-like antigen is widely distributed and present within both glia and neurons. Astrocytes were the most intensively labelled but many neuronal populations were also stained. In some regions including brain stem, spinal cord, hippocampus and diagonal band of Broca, neurons were stained at varying intensities. In other areas such as the cortex of the forebrain and amygdaloid nucleus, the stain was intense but diffuse, preventing positive identification of the cell types involved. Immunoblot results indicated two separate protein bands in all brain and spinal cord regions examined, of molecular weights 145 and 85 kDa, respectively. These findings aid the definition of neuronal and glial subpopulatio...Continue Reading

References

Jun 10, 1996·The Journal of Comparative Neurology·E Y ChenJ H Kordower
Oct 1, 1996·Molecular and Chemical Neuropathology·M A PelleymounterC Wellman
Aug 31, 1995·Mechanisms of Ageing and Development·J M TorresJ A Vega
Jul 21, 1995·Neuroscience Letters·T SalinN Belluardo
Feb 19, 2003·Brain Research. Brain Research Reviews·Sophie PezetStephen B McMahon
Jun 26, 1998·Brain Research. Brain Research Reviews·B Connor, M Dragunow
Feb 13, 1999·Progress in Neurobiology·M J Millan
Apr 16, 1998·Neuroscience Letters·T KohjiM Oda
Jun 5, 2004·Parkinsonism & Related Disorders·C KnottG P Wilkin
Jun 17, 2006·Annual Review of Neuroscience·Sophie Pezet, Stephen B McMahon
Dec 21, 2000·The European Journal of Neuroscience·J Y ZhangX F Zhou
Dec 7, 2007·British Journal of Pharmacology·A L CarvalhoC B Duarte
Jan 4, 2012·The European Journal of Neuroscience·Vanessa S BoyceLorne M Mendell
Nov 19, 2003·The European Journal of Neuroscience·Oliver von Bohlen und HalbachKlaus Unsicker
Oct 8, 2004·Expert Opinion on Therapeutic Targets·Sophie Pezet, Marzia Malcangio
Feb 13, 2001·Experimental Neurology·D J LieblLuis F Parada
Jun 1, 1997·Mechanisms of Development·T SchimmangJ Represa
Jun 21, 2008·Experimental Neurology·Li-Jun ZhouXian-Guo Liu
Aug 11, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hong-Tian ZhangTim Ting-Hua Wang

Citations

Jul 1, 1992·Journal of Neuroscience Research·L A HuttonJ R Perez-Polo
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N Y IpS Squinto
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C WetmoreL Olson
Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos

Related Concepts

Neurotrophic Tyrosine Kinase Receptor Type 2
Central Nervous System
Immunoblotting, Reverse
Cortex Bone Disorders
Adrenal Cortex Diseases
Immunoreactivity
Malignant Neoplasm of Spinal Cord
Neurons
Astrocytes
Recombinant Brain-Derived Growth Factors

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.