Distribution of tuft-shaped astrocytes in the cerebral cortex in progressive supranuclear palsy

Acta Neuropathologica
Yasushi IwasakiGen Sobue

Abstract

The deposition of abnormal levels of tau protein is a major neuropathological feature of progressive supranuclear palsy (PSP), and the presence of tuft-shaped astrocytes is a neuropathological hallmark of PSP. We examined the topographic distribution of tuft-shaped astrocytes in the cerebral hemisphere by Gallyas-Braak silver staining in three Japanese autopsy cases of typical PSP. The distribution of tuft-shaped astrocytes was relatively uniform between cases. Tuft-shaped astrocytes were identified predominantly in posterior frontal areas such as the precentral gyrus and premotor and supplementary motor areas (Brodmann areas 4, 6 and 8). Tuft-shaped astrocytes were most dense in areas of cortical convexity, and they were more abundant in the crests of the cerebral gyri than in the valleys of the cerebral sulci. The temporal, parietal and occipital cortices, including the hippocampal formation and cingulate gyrus, were relatively free of tuft-shaped astrocytes. We confirmed involvement of the cerebral cortex in the pathology of PSP, and showed the widespread presence of tuft-shaped astrocytes, particularly in the precentral gyrus and premotor and supplementary motor areas, to be an essential neuropathological feature of PSP. Th...Continue Reading

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Citations

May 28, 2005·Acta Neuropathologica·Yasushi IwasakiGen Sobue
Nov 4, 2006·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Mari Yoshida
Nov 28, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yasushi IwasakiMari Yoshida
Sep 29, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yasushi IwasakiGen Sobue
Jan 17, 2013·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yasushi IwasakiMari Yoshida
Aug 16, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Mari Yoshida
Jul 6, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Irene López-GonzálezIsidre Ferrer
Feb 11, 2015·Cellular and Molecular Life Sciences : CMLS·Sarah N FontaineChad A Dickey
Oct 26, 2016·Brain Research Bulletin·Thomas ArendtMax Holzer
Dec 18, 2013·Journal of Neuropathology and Experimental Neurology·Isidre FerrerGabor G Kovacs
Feb 18, 2016·Journal of Experimental Neuroscience·Martha A Kahlson, Kenneth J Colodner
Apr 3, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Yvette A M GrimbergenMarten Munneke
Mar 13, 2014·PloS One·Katrijn SmuldersBastiaan R Bloem

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