Distribution of type I collagen morphologies in bone: relation to estrogen depletion.

Bone
Joseph M WallaceMark M Banaszak Holl

Abstract

Bone is an amazing material evolved by nature to elegantly balance structural and metabolic needs in the body. Bone health is an integral part of overall health, but our lack of understanding of the ultrastructure of healthy bone precludes us from knowing how disease may impact nanoscale properties in this biological material. Here, we show that quantitative assessments of a distribution of Type I collagen fibril morphologies can be made using atomic force microscopy (AFM). We demonstrate that normal bone contains a distribution of collagen fibril morphologies and that changes in this distribution can be directly related to disease state. Specifically, by monitoring changes in the collagen fibril distribution of sham-operated and estrogen-depleted sheep, we have shown the ability to detect estrogen-deficiency-induced changes in Type I collagen in bone. This discovery provides new insight into the ultrastructure of bone as a tissue and the role of material structure in bone disease. The observation offers the possibility of a much-needed in vitro procedure to complement the current methods used to diagnose osteoporosis and other bone disease.

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Citations

Jun 15, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Petar MilovanovicZlatko Rakocevic
Feb 4, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Joseph M WallaceMark M Banaszak Holl
Jan 15, 2014·BoneKEy Reports·Ming Fang, Mark M Banaszak Holl
Jul 16, 2014·Climacteric : the Journal of the International Menopause Society·C LouH-Z Xu
Aug 15, 2015·International Journal of Endocrinology·Shidi HuYebin Jiang
Oct 22, 2015·Kidney International·Christopher L NewmanMatthew R Allen
Aug 11, 2010·Journal of Structural Biology·Joseph M WallaceMark M Banaszak Holl
Dec 15, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Taeyoung KimRong Wang
Mar 23, 2012·The Journal of Investigative Dermatology·Ming FangMark M Banaszak Holl
Oct 3, 2012·Biotechnology Journal·Blake EricksonMark M Banaszak Holl
Dec 24, 2013·Journal of Biomechanics·Armando Diaz GonzalezJoseph M Wallace
Nov 26, 2013·Journal of Solid State Chemistry·John-David P McElderryMichael D Morris
Apr 22, 2015·Calcified Tissue International·Patrick Garnero
May 12, 2015·ACS Nano·Eike-Christian SpitznerRobert Magerle
Jun 24, 2016·Journal of the Royal Society, Interface·Marios GeorgiadisPhilipp Schneider
Jan 24, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Ming FangMark M Banaszak Holl
Jun 14, 2017·Menopause : the Journal of the North American Menopause Society·Chao LouDengwei He
Nov 18, 2014·Journal of Biomedical Optics·Alexander J MakowskiJeffry S Nyman
Feb 25, 2021·Journal of Pediatric Urology·Kristin E WhitneyKathryn E Ackerman
Apr 18, 2018·Biomacromolecules·Rachel L MerzelMark M Banaszak Holl
Oct 12, 2021·Microscopy Research and Technique·Anas K Al MakhzoomiGarry T Allison

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