Distribution of urocortin 3 neurons innervating the ventral premammillary nucleus in the rat brain

Brain Research
Judney Cley CavalcanteCarol F Elias

Abstract

Urocortin 3 (Ucn 3) is a recently described peptide of the corticotropin-releasing factor family. Neurons expressing Ucn 3 mRNA and peptide are distributed in specific brain areas, including the median preoptic nucleus, the perifornical area (PFx), and the medial nucleus of the amygdala (MEA). Fibers immunoreactive to Ucn 3 are confined to certain brain nuclei, being particularly dense in the ventral premammillary nucleus (PMV). In studies involving electrolytic lesions and analysis of Fos distribution according to behavioral paradigms, the PMV has been potentially implicated in conspecific aggression and sexual behavior. However, the role that Ucn 3 plays in this pathway has not been explored. Therefore, we investigated the origins of the urocortinergic innervation of the PMV of Wistar rat in an attempt to map the brain circuitry and identify likely related functions. We injected the retrograde tracer cholera toxin b subunit into the PMV and found that 88% of the Ucn 3-immunoreactive fibers in the PMV originate in the dorsal MEA, and that few originate in the PFx. As a control, we injected the anterograde tracer biotin dextran amine into both regions. We observed that the PMV is densely innervated by the MEA, and scarcely inne...Continue Reading

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Citations

Mar 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca L LeshanMartin G Myers
Aug 2, 2014·Brain Research·Judney Cley CavalcanteCarol Fuzeti Elias
Aug 31, 2014·Journal of Chemical Neuroanatomy·Rebecca L Leshan, Donald W Pfaff
Oct 28, 2009·Physiology & Behavior·Jose DonatoCarol Fuzeti Elias
Nov 7, 2006·Frontiers in Neuroendocrinology·Eva M Fekete, Eric P Zorrilla
Dec 15, 2007·CNS Drug Reviews·Catherine Borna FarrokhiJoachim Spiess
Jun 3, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Carolina Böettge RosaAlberto A Rasia-Filho
Nov 5, 2016·The European Journal of Neuroscience·Mariana ZancanAlberto A Rasia-Filho
Apr 11, 2017·The Journal of Comparative Neurology·Sylvia V H GrommenBert De Groef

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