Distribution of vesicular glutamate transporters in rat and human retina

Brain Research
Jie GongSerge Picaud

Abstract

Central nervous system neurons have traditionally been thought to express exclusively membrane transporters and/or vesicular transporters for their transmitter. Three vesicular glutamate transporters have recently been cloned: BNPI/VGLUT1 (a brain-specific sodium-dependent inorganic phosphate (Pi) transporter), and its homologs DNPI/VGLUT2 (differentiation-associated sodium-dependent Pi transporter) and VGLUT3. We investigated the subcellular distributions of these three vesicular transporters in rat and human retina. VGLUT1 was present in the outer and inner plexiform layers (OPL and IPL), as shown by punctate staining in both human and rat retina. In the OPL, it was colocalized with synaptophysin, consistent with its expression in glutamatergic photoreceptor terminals, and it was present in PKC-alpha-labeled glutamatergic bipolar cell terminals in the IPL. By contrast, VGLUT2 was present in horizontal cells and ganglion cells in rat and human retina. In human retina, VGLUT2 was also found in some amacrine cells, including GAD-immunopositive amacrine cells. VGLUT3 was present in glycine-releasing amacrine cells in rat retina but was restricted to a few ganglion cells in human retina. The distribution of VGLUT1 in excitatory sy...Continue Reading

References

Jul 1, 1991·Visual Neuroscience·H WässleF Müller
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·S PicaudF Werblin
Sep 1, 1994·Neuron·J D RothsteinR W Kuncl
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·B NiS M Paul
Jun 17, 1996·The Journal of Comparative Neurology·J H BrandstätterH Wässle
Dec 1, 1996·Cell and Tissue Research·T RauenH Wässle
Dec 1, 1996·The Journal of Physiology·M TakahashiD Attwell
Jan 1, 1997·Microscopy Research and Technique·J Nguyen-LegrosC Savy
Oct 29, 1997·Histochemistry and Cell Biology·H UedaS Ohno
Jul 31, 1998·Visual Neuroscience·M A Johnson, N Vardi
Jun 15, 1999·Visual Neuroscience·D V Pow, A E Hendrickson
Oct 26, 1999·Progress in Retinal and Eye Research·W B Thoreson, P Witkovsky
Nov 17, 1999·The European Journal of Neuroscience·J H BrandstätterH Wässle
Jul 4, 2001·The Journal of Biological Chemistry·L BaiF K Ghishan
Jul 12, 2001·The Journal of Comparative Neurology·S HaverkampH Wässle
Mar 29, 2002·The Journal of Comparative Neurology·Juan G CuevaNicholas C Brecha
Jul 13, 2002·The Journal of Comparative Neurology·Abdeljalil JellaliSerge Picaud
Sep 21, 2002·Cell and Tissue Research·Michael WiessnerThomas Rauen
Oct 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert T FremeauRobert H Edwards
Dec 7, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ognen A C Petroff
Dec 4, 2003·The Journal of Comparative Neurology·Silke Haverkamp, Heinz Wässle
Aug 27, 2004·The Journal of Comparative Neurology·Juliette JohnsonDavid R Copenhagen
Aug 27, 2004·The Journal of Comparative Neurology·Silke HaverkampHeinz Wässle

❮ Previous
Next ❯

Citations

Apr 18, 2008·Journal of Molecular Neuroscience : MN·Tamas AtlaszRobert Gabriel
Mar 3, 2009·Molecular Neurobiology·George Zanazzi, Gary Matthews
Aug 26, 2011·Visual Neuroscience·William N GrimesJeffrey S Diamond
Aug 15, 2014·Journal of Chemical Neuroanatomy·Yasuro Atoji, Mohammad Rabiul Karim
Jan 16, 2016·Experimental Eye Research·Clairton F de SouzaMonica L Acosta
Jun 16, 2009·Experimental Eye Research·Mohammad Rafiqul Islam, Yasuro Atoji
Mar 24, 2007·Experimental Eye Research·Claudia M DiazDavid V Pow
Jul 24, 2012·The Journal of Comparative Neurology·Sonja Neumann, Silke Haverkamp
Oct 19, 2011·The Journal of Comparative Neurology·Theresa PuthusserySilke Haverkamp
Dec 17, 2014·Experimental Eye Research·Elena CaminosJuan R Martinez-Galan
Dec 7, 2013·Acta Physiologica Hungarica·K SzabadfiR Gabriel
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Minggang ChenZ Jimmy Zhou
Apr 9, 2020·Proceedings of the National Academy of Sciences of the United States of America·Timothy J CherryMichael E Greenberg
Feb 22, 2007·The Journal of Comparative Neurology·Bozena Fyk-Kolodziej, Roberta G Pourcho
Mar 14, 2013·International Journal of Molecular Medicine·Kang LiuYuxiao Zeng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.