Distribution of virulence-associated genes and antimicrobial susceptibility in clinical Acinetobacter baumannii isolates

Oncotarget
Chao LiuXu Jia

Abstract

Acinetobacter baumannii is undoubtedly one of the most clinically significant pathogens. The multidrug resistance and virulence potential of A. baumannii are responsible for hospital-acquired nosocomial infections. Unlike numerous investigations on the drug-resistant epidemiology of A. baumanni, virulence molecular epidemiology is less studied. Here, we collected 88 A. baumannii clinical isolates, tested their antimicrobial susceptibility to 10 commonly used antibiotics and analyzed the distribution of 9 selected virulence-associated genes, aims to investigate the primary characteristics of the virulence-associated genes that exist in clinically multidrug resistant (MDR) and non-MDR isolates of A. baumannii. The MIC results showed the resistance rates of ciprofloxacin (68.2%, 60/88), gentamicin (67.0%, 59/88), amikacin (58.0%, 51/88), tobramycin (58.0%, 51/88), doxycycline (67.0%, 59/88), meropenem (54.5%, 48/88) and imipenem (65.9%, 58/88) were all above 50%, except for levofloxacin (34.1%, 30/88), minocycline (1.1%, 1/88) and polymyxin B (0%, 0/88). The Pulsed field gel electrophoresis (PFGE) analysis revealed that the resistance rate of MDR A. baumannii isolates in the Epidemic group was predominant (79.5%, 44/58), but in th...Continue Reading

References

May 3, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Maria Virginia Villegas, Alan I Hartstein
Oct 12, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M-L Joly-Guillou
Feb 20, 2007·International Journal of Antimicrobial Agents·Matthew E Falagas, Ioannis A Bliziotis
Jun 5, 2007·Critical Care : the Official Journal of the Critical Care Forum·Matthew E Falagas, Petros I Rafailidis
Nov 6, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A van BelkumUNKNOWN European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group on Epidemiological Markers (ESGEM)
Nov 21, 2007·Journal of Bacteriology·Thomas W LoehfelmAnthony A Campagnari
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa L Maragakis, Trish M Perl
Nov 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen W BoucherJohn Bartlett
Sep 15, 2009·The Journal of Infection·Matthieu EveillardMarie-Laure Joly-Guillou
Mar 3, 2010·Infection and Immunity·Anna C JacobsPaul M Dunman
Oct 16, 2010·Nature Reviews. Microbiology·Harald Nothaft, Christine M Szymanski
Aug 15, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·UNKNOWN Infectious Diseases Society of America
Jun 21, 2013·Molecular Microbiology·Robert G Lees-MillerMario F Feldman
Aug 3, 2013·The Journal of Infectious Diseases·Younes SmaniJerónimo Pachón
Sep 24, 2013·Journal of Structural Biology·Andrey M GrishinMiroslaw Cygler
Oct 10, 2013·BioMed Research International·Fatemeh SefidAbolfazl Jahangiri
Jan 17, 2014·The Journal of Infectious Diseases·Gustavo M CerqueiraAnton Y Peleg
Apr 17, 2014·Critical Care Medicine·Brad Spellberg, Robert A Bonomo
Dec 18, 2014·World Journal of Clinical Cases·Ming-Feng Lin, Chung-Yu Lan
Feb 3, 2015·Seminars in Respiratory and Critical Care Medicine·Yohei DoiAnton Y Peleg
Dec 30, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Maristela Pinheiro FreireEdson Abdala
Mar 24, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F-P HuW Huang
May 26, 2016·Journal of Microbiology and Biotechnology·Ji Youn SungGye Cheol Kwon
Aug 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Md Saruar BhuiyanAnton Y Peleg

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Citations

Jul 19, 2019·Journal of Clinical Laboratory Analysis·Li-Jing ZhuPan-Fei Hou
Sep 13, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Zahra AghajaniSeyed Latif Mousavi Gargari
Feb 23, 2019·Frontiers in Microbiology·Jetsi Mancilla-RojanoAriadnna Cruz-Córdova
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Xiufeng ZhangWeibiao Lv

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Methods Mentioned

BETA
Electrophoresis
PCR
genotyping

Software Mentioned

BioNumerics

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