PMID: 20103992Jan 28, 2010Paper

Distribution of virulence genes related to adhesins and toxins in shiga toxin-producing Escherichia coli strains isolated from healthy cattle and diarrheal patients in Japan

The Journal of Veterinary Medical Science
Yuluo WuShinji Yamasaki

Abstract

Shiga toxin-producing Escherichia coli (STEC) isolated from Japan were investigated for the distribution of virulence genes. A total of 232 STEC strains including 171 from cattle and 61 from human were examined for the occurrence of genes responsible for bacterial adhesions to intestine, e.g., eae (intimin, E. coli attaching and effacing), saa (STEC autoagglutinating adhesin), iha (irgA homologue adhesin), efa1 (E. coli factor for adherence), lpfA(O113) (long polar fimbriae), and ehaA (EHEC autotransporter) by colony hybridization assay. Similarly, the presence of toxigenic cdt (cytolethal distending toxin), and subAB (subtilase cytotoxin) genes were also checked. Among cattle isolates, 170, 163, 161, 155, 112 and 84 were positive for lpfA(O113) (99%), ehaA (95%), iha (94%), saa (91%), subAB (65%), and cdt-V (49%), respectively, while 2 were positive for eae (1.2%) and efa1 (1.2%) each. In case of human isolates, 60, 59, 58 and 58 were positive for ehaA (98%), iha (97%), efa1 (95%), and eae (95%), respectively, while 11, 2, 2, and 1 were positive for lpfA(O113) (18%), saa (3.3%), cdt-V (3.3%), and subAB (1.6%), respectively. Therefore, in human STEC isolates efa1 and eae whereas in cattle isolates saa, lpfA(O113), cdt-V and sub...Continue Reading

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Citations

Sep 3, 2010·Nihon saikingaku zasshi. Japanese journal of bacteriology·Kinnosuke Yahiro
Aug 30, 2013·Nihon saikingaku zasshi. Japanese journal of bacteriology·Masatoshi Noda
Oct 5, 2010·Applied and Environmental Microbiology·Donna E DavidSteven L Foley
Jan 30, 2016·International Journal of Food Microbiology·Rabee A OmbarakShinji Yamasaki
Sep 14, 2014·Microbiology·Zoran JaglicSusanne Knøchel
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