Distribution patterns of mRNAs encoding glycine receptor channels in the developing rat spinal cord

Neuroscience Research
E Watanabe, H Akagi

Abstract

The developmental changes in the expression of mRNAs encoding the alpha 1 and alpha 2 subunits of inhibitory glycine receptors in the spinal cord of fetal and postnatal rats were examined by in situ hybridization. During embryonic periods (E11-18), the mantle zone was scarce in the alpha 1 mRNA, but the germinal zone (matrix layer) at E11-14 expressed higher levels of the message. At postnatal day 0 (P0), the alpha 1 signals became manifested throughout the gray matter of the spinal cord. The intensities of the signals were increased to reach a maximal level at P21. By contrast, the spinal tissues at P0 exhibited the highest levels of alpha 2 mRNA, which decreased with the postnatal development. In P50 rats, the alpha 2 mRNA was barely expressed in the ventral horn, but a significant number of grains could still be detectable in a population of cells in the dorsal horn. During postnatal development from P0 to P10, the spinal tissues were rich in the alpha 1 and alpha 2 mRNAs, both of which were detected in the presumed motoneurons. The coexistence of the two subunits in single neurons might correlate with the modification of the glycine receptor function during the development of the spinal cord.

References

Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H AkagiR Miledi
Dec 15, 1993·The Journal of Comparative Neurology·W MaJ L Barker

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Citations

Apr 15, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bahram MohammadiJohannes Bufler
Jun 1, 1997·Brain Research. Brain Research Reviews·R E Coggeshall, S M Carlton
Feb 2, 2011·The Journal of General Physiology·Paraskevi KrashiaLucia G Sivilotti
Jul 22, 1999·Annals of the New York Academy of Sciences·H BetzR J Harvey
Jan 19, 2016·Histochemistry and Cell Biology·Chrysovalandis SchwaleJochen Kuhse
Jun 30, 2011·Neuroscience Research·Hiromi HirataKazutoyo Ogino
May 21, 2005·The Journal of Physiology·Paul S MillerTrevor G Smart
Aug 21, 2013·Cell Reports·Ariel AvilaLaurent Nguyen
Aug 30, 2008·Neuropharmacology·Joseph W Lynch
Jul 26, 2016·Frontiers in Molecular Neuroscience·Kazutoyo Ogino, Hiromi Hirata
Jul 9, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·C ReynosoJ Narbona
Dec 15, 2016·Journal of Natural Products·Amal M Y MohsenDarius P Zlotos
Sep 12, 2000·The Journal of Comparative Neurology·E J GeimanF J Alvarez
Apr 5, 2018·BMC Genomics·Peter V LovellClaudio V Mello
Oct 24, 2017·Developmental Neurobiology·Min-Shan LinXin-Hong Zhu
Sep 24, 2004·Physiological Reviews·Joseph W Lynch
Oct 1, 2004·Journal of Neurophysiology·Gautam B AwatramaniLaurence O Trussell
Apr 12, 2007·International Anesthesiology Clinics·Mark L Baccei
Aug 16, 2012·The Journal of Pharmacology and Experimental Therapeutics·Li WangYong Li
Dec 29, 2007·Molecular Pharmacology·Xiao-Bing ZhangTian-Le Xu
Aug 24, 2017·Alcoholism, Clinical and Experimental Research·Bo SöderpalmMia Ericson
May 2, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S GallegosL G Aguayo
Sep 25, 2014·Biomedit︠s︡inskai︠a︡ khimii︠a︡·V N Nikandrov, T V Balashevich
Nov 30, 2018·Frontiers in Molecular Neuroscience·Elena PetukhovaPiotr Bregestovski
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Dec 2, 2004·Brain Research. Brain Research Reviews·Luis G AguayoFrancisco J Alvarez
Sep 7, 2017·Journal of Medicinal Chemistry·Christopher L Cioffi
Sep 4, 2014·Biochemistry·Rilei YuPhilip C Biggin

❮ Previous
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