Distribution Patterns of Polyphosphate Metabolism Pathway and Its Relationships With Bacterial Durability and Virulence

Frontiers in Microbiology
Liang WangDaoquan Tang

Abstract

Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate residues. It is reported to be present in all life forms. Experimental studies showed that polyP plays important roles in bacterial durability and virulence. Here we investigated the relationships of polyP with bacterial durability and virulence theoretically. Bacterial lifestyle, environmental persistence, virulence factors (VFs), and species evolution are all included in the analysis. The presence of seven genes involved in polyP metabolism (ppk1, ppk2, pap, surE, gppA, ppnK, and ppgK) and 2595 core VFs were verified in 944 bacterial reference proteomes for distribution patterns via HMMER. Proteome size and VFs were compared in terms of gain and loss of polyP pathway. Literature mining and phylogenetic analysis were recruited to support the study. Our analyzes revealed that the presence of polyP metabolism is positively correlated with bacterial proteome size and the number of virulence genes. A potential relationship of polyP in bacterial lifestyle and environmental durability is suggested. Evolutionary analysis shows that polyP genes are randomly lost along the phylogenetic tree. In sum, based on our theoretical analysis, we confirmed that bacteria with p...Continue Reading

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Citations

Jun 4, 2019·G3 : Genes - Genomes - Genetics·Liang WangMichael J Wise
Aug 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Kasper U KjeldsenAndreas Schramm
Jan 4, 2020·World Journal of Microbiology & Biotechnology·Liang WangWei Wang
Feb 2, 2019·Scientific Reports·Liang WangChunying Wang
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May 1, 2021·Polymers·Sreejita GhoshRina Rani Ray
Sep 5, 2021·Trends in Microbiology·Kabir BhallaJames W Kronstad

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Methods Mentioned

BETA
phosphotransferase

Software Mentioned

HMMER
HMM
VF
R
phyloT
ggplot2
iTOL
hmmsearch
BLAST
PATRIC

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