Distribution profile of gadolinium in gadolinium chelate-treated renally-impaired rats: role of pharmaceutical formulation

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Nathalie FretellierClaire Corot

Abstract

While not acutely toxic, chronic hepatic effect of certain gadolinium chelates (GC), used as contrast agent for magnetic resonance imaging, might represent a risk in renally-impaired patients due to free gadolinium accumulation in the liver. To answer this question, this study investigated the consequences of the presence of small amounts of either a soluble gadolinium salt ("free" Gd) or low-stability chelating impurity in the pharmaceutical solution of gadoteric acid, a macrocyclic GC with high thermodynamic and kinetic stabilities, were investigated in renally-impaired rats. Renal failure was induced by adding 0.75% adenine in the diet for three weeks. The pharmaceutical and commercial solution of gadoteric acid was administered (5 daily intravenous injections of 2.5 mmol Gd/kg) either alone or after being spiked with either "free" gadolinium (i.e., 0.04% w/v) or low-stability impurity (i.e., 0.06 w/v). Another GC, gadodiamide (low thermodynamic and kinetic stabilities) was given as its commercial solution at a similar dose. Non-chelated gadolinium was tested at two doses (0.005 and 0.01 mmol Gd/kg) as acetate salt. Gadodiamide induced systemic toxicity (mortality, severe epidermal and dermal lesions) and substantial tissue ...Continue Reading

References

Jan 1, 1986·Cancer Immunology, Immunotherapy : CII·H J PearsonP R Bell
Jul 1, 1993·Nuclear Medicine and Biology·P WedekingM F Tweedle
Sep 1, 1996·Toxicologic Pathology·A J WassermanS K Durham
May 1, 1997·Toxicologic Pathology·A J SpencerE Harpur
Aug 4, 2006·Journal of the American Society of Nephrology : JASN·Peter MarckmannHenrik S Thomsen
Dec 8, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Simona BussiAlberto Morisetti
Mar 18, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Marc PortClaire Corot
Apr 4, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Josef A SchroederBernhard K Krämer
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·Jean-Marc IdéeClaire Corot
Jan 16, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jin-Xia LiXiao-Gai Yang
Jul 22, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Thaddeus J WadasCarolyn J Anderson
Apr 13, 2011·Biological Trace Element Research·William JenkinsJames Varani
May 3, 2011·Advances in Chronic Kidney Disease·Ali K Abu-Alfa
Jul 12, 2011·British Journal of Pharmacology·N FretellierC Corot
Sep 2, 2011·Biological Trace Element Research·Katherine BleavinsJames Varani
Sep 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nathalie FretellierClaire Corot
Oct 24, 2012·Journal of Magnetic Resonance Imaging : JMRI·Dapeng HaoMichael Tweedle
Jan 31, 2014·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·J T HeverhagenE Gizewski
Sep 27, 2014·Critical Reviews in Toxicology·Jean-Marc IdéeClaire Corot

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Citations

Mar 24, 2016·Bioorganic & Medicinal Chemistry·Xiaolu BaoZhilong Chen
Jul 12, 2017·Acta Radiologica·Henrik S Thomsen
Oct 19, 2017·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Joel GarciaAngelique Y Louie
Mar 20, 2019·International Journal of Molecular Sciences·Claudia BonechiAgnese Magnani
Apr 3, 2018·Journal of Magnetic Resonance Imaging : JMRI·Tolga MercantepeAdnan Yilmaz
Apr 22, 2021·Advanced Healthcare Materials·Gary StinnettVicki L Colvin

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