Distribution, spherical structure and predicted Mie scattering of multilamellar bodies in human age-related nuclear cataracts

Experimental Eye Research
Kurt O GillilandM Joseph Costello

Abstract

To characterize multilamellar bodies (MLBs), determine their distribution along the optic axis and predict their potential Mie scattering within human age-related nuclear cataracts. Previous studies restricted to the equatorial plane have shown that MLBs are rare spherical objects that are 1-4 microm in diameter and covered by multiple layers of thin lipid-rich membranes. Eight human aged transparent lenses were obtained from eye bank donors and eight human age-related nuclear cataracts were obtained immediately after extracapsular extraction. Each sample was Vibratome sectioned fresh into 200 microm thick sections that were fixed and embedded for light or electron microscopy. Light micrograph montages of the optic axis containing the juvenile, fetal and embryonic nuclei were examined. Mie scattering for random coated spherical particles was calculated based on assumed and measured particle parameters. Cells along the optic axis of the cataract contained approximately 7.5 times more MLBs as similar regions of the aged transparent lens, although these MLBs occurred with extremely low frequency. Cells of the aged transparent lens contained 1.3 MLBs mm(-2), while those of the cataract contained 9.6 MLBs mm(-2), which are equivalen...Continue Reading

References

Jan 1, 1979·International Review of Cytology·A F Hayward
Oct 1, 1979·Experimental Eye Research·G Y MousaJ R Trevithick
Jan 1, 1979·Archives of Ophthalmology·J V Greiner, L T Chylack
Jun 1, 1989·The Journal of Cell Biology·G A ZampighiS A Simon
Jul 1, 1988·Mechanisms of Ageing and Development·M A BabizhayevL F Linberg
Jan 1, 1985·Progress in Lipid Research·R O Scow, E J Blanchette-Mackie
Nov 1, 1985·Current Eye Research·M J CostelloJ D Robertson
Apr 1, 1982·The Journal of Cell Biology·G ZampighiM J Costello
Dec 1, 1981·Experimental Eye Research·P P FagerholmB Lindström
Dec 1, 1981·Experimental Eye Research·B T Philipson, P P Fagerholm
Dec 1, 1981·Journal of Ultrastructure Research·E J Blanchette-Mackie, R O Scow
Oct 1, 1993·Experimental Eye Research·K J al-Ghoul, M J Costello
May 1, 1996·Current Eye Research·K J al-Ghoul, M J Costello
Mar 1, 1996·Experimental Eye Research·K J Al-GhoulM J Costello
Jun 1, 1997·Experimental Eye Research·B K Pierscionek
Oct 23, 1997·Investigative Ophthalmology & Visual Science·G B Benedek
Aug 26, 1998·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·R MichaelE Chen
Apr 7, 1999·Progress in Retinal and Eye Research·G B BenedekJ I Clark
May 27, 1999·Vision Research·T J van den Berg, H Spekreijse
Jan 19, 2000·Molecular Biology of the Cell·M HaririI R Nabi
Aug 10, 2000·Biochimica Et Biophysica Acta·K MatsuzakiS Kobayashi
Sep 6, 2000·Ophthalmic Research·R J Truscott
Apr 17, 2003·Experimental Eye Research·Daxin TangDonald B DuPré
Jun 26, 2003·Experimental Eye Research·Ralph MichaelThomas J T P van den Berg
Jun 23, 1959·The Journal of Physiology·G V BORN, J BRICKNELL
Oct 27, 2004·Experimental Eye Research·Stefania MarsiliM Joseph Costello
Mar 1, 1971·Applied Optics·G B Benedek

❮ Previous
Next ❯

Citations

Aug 10, 2006·Japanese Journal of Ophthalmology·Toshifumi MihashiTakashi Fujikado
Aug 17, 2012·Journal of Biomedical Optics·Yi-Chun ChenChing-Cherng Sun
Dec 22, 2007·BMC Ophthalmology·Samer Al-KhudariKristin J Al-Ghoul
Apr 22, 2010·Journal of Lipid Research·Douglas Borchman, Marta C Yappert
May 20, 2014·Progress in Biophysics and Molecular Biology·Eugene Serebryany, Jonathan A King
Nov 18, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sofija AndjelicMarko Hawlina
Dec 11, 2013·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Ismael Kelly-PérezJosé A Delgado Atencio
Oct 5, 2010·Experimental Eye Research·M Joseph CostelloDorairajan Balasubramanian
Feb 3, 2009·Journal of Cataract and Refractive Surgery·David V FoldenDonald J Doughman
Jul 12, 2008·Experimental Eye Research·M J CostelloDorairajan Balasubramanian
Jul 27, 2007·American Journal of Ophthalmology·Thomas J T P Van Den BergLuuk Franssen
Jul 23, 2013·Experimental Eye Research·Jonathan A WignesUsha P Andley
Jun 17, 2015·TheScientificWorldJournal·Karine JoulanNicolas Hautière
Sep 10, 2013·Experimental Eye Research·M Joseph CostelloMarc Kantorow
Mar 9, 2017·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Thomas J T P van den Berg
Mar 3, 2018·Journal of Biophotonics·Ismael Kelly-PérezThomas Bende
May 30, 2019·Integrative and Comparative Biology·Laura E Bagge
Jun 13, 2018·Journal of Cataract and Refractive Surgery·José J Esteve-TaboadaTeresa Ferrer-Blasco
Oct 30, 2016·Current Eye Research·Laxman MainaliWitold K Subczynski
Mar 17, 2021·Investigative Ophthalmology & Visual Science·Jessica M SkeieMark A Greiner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.