Distributions and determinants of urinary biomarkers of organophosphate pesticide exposure in a prospective Spanish birth cohort study

Environmental Health : a Global Access Science Source
Sabrina LlopFerran Ballester

Abstract

Prenatal exposure to organophosphate pesticides (OPs) has been associated with impaired child development. Pesticide exposure determinants need to be studied in order to identify sources and pathways of pesticide exposure. The aim of this paper is to describe prenatal exposure to OPs and evaluate the associated factors in pregnant women. The study population consisted of pregnant women (n = 573) who participated in the INMA birth cohort study in Valencia (Spain, 2003-2006). OP metabolites were analyzed in maternal urine at the 32nd week of gestation using a liquid chromatography-high resolution mass spectrometry method. The analysis included non-specific (diethyl phosphate [DEP], diethyl thiophosphate [DETP], dimethyl thiophosphate [DMTP], dimethyl dithiophosphate [DMDTP]) and specific metabolites (2-diethylamino-6-methyl-4-pyrimidinol [DEAMPY], 2-isopropyl-4-methyl-6-hydroxypyrimidine [IMPY], para-nitrophenol [PNP], and 3,5,6-trichloro-2-pyridinol [TCPY]). Information about the sociodemographic, environmental, and dietary characteristics was obtained by questionnaire. The association between log-transformed OPs and covariates was analyzed using multivariable interval censored regression. The detection frequencies were low, DMT...Continue Reading

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Citations

Jan 29, 2019·Environmental Health Perspectives·Todd A JuskoMatthew P Longnecker
Aug 17, 2019·Environmental Health Perspectives·Kelly K FergusonVincent W V Jaddoe
Apr 17, 2021·Environmental Science and Pollution Research International·Boonsita SuwannakulSurat Hongsibsong
Apr 12, 2021·Environmental Pollution·Hongxiu LiuAkhgar Ghassabian
Apr 16, 2021·Journal of Perinatal Medicine·Esther Álvarez-SilvaresElena Martínez-Carballo
Jul 27, 2021·Frontiers in Endocrinology·María Mercedes MilesiJorgelina Varayoud
Dec 1, 2017·Environmental Science & Technology·Raf AertsAn Van Nieuwenhuyse

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