Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations.

Journal of Zhejiang University. Science. B
Bo-feng ZhuRudolf Lucas

Abstract

To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China. DNA typing for HLA-A and -B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and -B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A*2402 (32.46%), A*1101 (26.32%), and A*0203 (10.09%) at the HLA-A locus and B*4601 (12.28%), B*1525 (10.09%), B*4001 (8.77%), and B*3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A*2402-B*1525 (7.86%) and A*0203-B*3802 (5.64%), followed by A*1101-B*4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that...Continue Reading

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Citations

Aug 27, 2011·Journal of Assisted Reproduction and Genetics·Dang-Xia ZhouHong Tian
Nov 10, 2012·Human Immunology·Chun-mei ShenBo-feng Zhu
Nov 22, 2013·International Journal of Immunogenetics·D JawdatA Hajeer
Jan 27, 2017·Annual Review of Public Health·Gordon G LiuXuezhi Hong

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Methods Mentioned

BETA
PCR
chip

Software Mentioned

MatchTools Allele Identification package
Sequencing Analysis
Arlequin
PowerStat
MatchTools Navigator
SPSS
Mega3

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